转氨酶
胺气处理
化学
烷基
生物合成
氨基酸
有机化学
组合化学
生化工程
酶
生物化学
工程类
作者
Zhongxia Li,Yan Liu,Quan Luo,Xuefeng Lü
出处
期刊:PubMed
日期:2023-08-25
卷期号:39 (8): 3169-3187
标识
DOI:10.13345/j.cjb.220908
摘要
ω-transaminases are able to catalyze the reversible transfer of amino groups between diverse amino compounds (such as amino acids, alkyl amines, aromatic amines) and carbonyl compounds (such as aldehydes, ketones, ketoacids). ω-transaminases exhibit great application prospects in the field of chiral amine biosynthesis because of their desirable properties, such as wide range of substrates, high stereoselectivity, and mild catalytic conditions. It is therefore important for China to develop efficient, specific, and environment-friendly chiral amine production technologies with independent intellectual property rights, which is of great significance for the development of pharmaceutical, pesticide, and material industries. This review systematically summarizes the Chinese patents regarding ω-transaminase filed by Chinese institutions in the recent decade. The development of ω-transaminase resource, enzymatic property improvement by protein engineering, application in chiral amine synthesis, and development of production technologies are elaborated. This review will shed light on further basic and application studies of ω-transaminase.
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