动力蛋白
转移
癌细胞
微管
乳腺癌转移
微尺度化学
细胞生物学
癌症
乳腺癌
生物
神经科学
癌症转移
心理学
数学教育
遗传学
作者
Yerbol Tagay,Sina Kheirabadi,Zaman Ataie,Rakesh K. Singh,Olivia Prince,Ashley Nguyen,Alexander S. Zhovmer,Xuefei Ma,Amir Sheikhi,Denis Tsygankov,Erdem D. Tabdanov
标识
DOI:10.1002/advs.202302229
摘要
Abstract The principal cause of death in cancer patients is metastasis, which remains an unresolved problem. Conventionally, metastatic dissemination is linked to actomyosin‐driven cell locomotion. However, the locomotion of cancer cells often does not strictly line up with the measured actomyosin forces. Here, a complementary mechanism of metastatic locomotion powered by dynein‐generated forces is identified. These forces arise within a non‐stretchable microtubule network and drive persistent contact guidance of migrating cancer cells along the biomimetic collagen fibers. It is also shown that the dynein‐powered locomotion becomes indispensable during invasive 3D migration within a tissue‐like luminal network formed by spatially confining granular hydrogel scaffolds (GHS) made up of microscale hydrogel particles (microgels). These results indicate that the complementary motricity mediated by dynein is always necessary and, in certain instances, sufficient for disseminating metastatic breast cancer cells. These findings advance the fundamental understanding of cell locomotion mechanisms and expand the spectrum of clinical targets against metastasis.
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