Ru(II)-Catalyzed N-Methylation of Amines Using Methanol as the C1 Source

Four ruthenium complexes were used as catalysts for the N-methylation of amines using methanol as the C1 source under weak base conditions. The (DPEPhos)RuCl2PPh3(1a) catalyst showed the best catalytic performance (0.5 mol %, 12 h). The deuterium labeling and control experiments suggested the reaction via the Ru–H mechanism. This study provides a new ruthenium catalyst system for N-methylation with methanol under weak base conditions.