Distinct increase in antimicrobial resistance genes among Vibrio parahaemolyticus in recent decades worldwide

副溶血性弧菌 毒力 生物 抗生素耐药性 微生物学 抗生素 抗菌剂 病菌 生物技术 基因 细菌 遗传学
作者
Guan-Yu Fang,Xingquan Liu,Xiao-Jing Mu,Bing-Wen Huang,Yujian Jiang
出处
期刊:Chemosphere [Elsevier BV]
卷期号:340: 139905-139905 被引量:6
标识
DOI:10.1016/j.chemosphere.2023.139905
摘要

Vibrio parahaemolyticus is a common pathogen, and has emerged with multiple antimicrobial resistance (AMR). However, few studies have conducted large-scale investigations of AMR and virulence trends of V. parahaemolyticus worldwide. This study longitudinally monitored antibiotic resistance genes (ARGs) and virulence factor genes (VFGs) trends of 1540 V. parahaemolyticus isolates isolated from 1951 to 2021. The number of ARGs in V. parahaemolyticus isolates distinctly increased over the years (P = 5.9e-10), while the number of VFGs decreased significantly (P < 2.2e-16). However, the number of VFGs of isolates isolated from humans has not changed significantly over the years (R = 0.013, P = 0.74), suggesting that the pathogenic risk to humans has not been reduced. Besides, mobile genetic elements are important contributors to ARGs in V. parahaemolyticus (R = 0.34, P < 2.2e-16), but have no promoting effect on VFGs (P = 0.50). The structural equation model illustrated that the human development index promoted the consumption of antibiotics, thereby indirectly promoting an increase in the AMR of the V. parahaemolyticus isolates. Finally, the random forest was performed to predict the ARG and VFG risks of global terrestrial V. parahaemolyticus isolates, and successfully map these threats with over 80% accuracy. This study aimed to evaluate the global risks posed by AMR and virulence, which helps to develop methods specifically targeting V. parahaemolyticus to mitigate these threats.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
刚刚
刚刚
xioabu发布了新的文献求助10
刚刚
慕青应助fkhuny采纳,获得10
1秒前
上官若男应助研友_8KAOBn采纳,获得10
2秒前
2秒前
2秒前
3秒前
沙河口大长硬完成签到,获得积分10
3秒前
3秒前
盖小包完成签到 ,获得积分10
3秒前
希望天下0贩的0应助yyds采纳,获得10
3秒前
4秒前
4秒前
5秒前
qaz发布了新的文献求助10
6秒前
6秒前
迪迦发布了新的文献求助10
6秒前
乌波菲发布了新的文献求助10
6秒前
能干耳机发布了新的文献求助10
6秒前
海带拳大力士完成签到,获得积分10
8秒前
8秒前
zhaoqing完成签到,获得积分10
8秒前
丘比特应助王含爽采纳,获得10
8秒前
johnny发布了新的文献求助10
9秒前
思源应助MY2720采纳,获得10
11秒前
11秒前
冷酷严青发布了新的文献求助10
11秒前
11秒前
11秒前
曾经盼易发布了新的文献求助10
12秒前
12秒前
12秒前
吕小软完成签到,获得积分10
13秒前
万能图书馆应助Dora采纳,获得30
13秒前
丘比特应助逆向追逐采纳,获得10
13秒前
朴素亦绿完成签到,获得积分10
13秒前
上官若男应助姚玲采纳,获得10
13秒前
852应助姚玲采纳,获得20
13秒前
13秒前
高分求助中
【提示信息,请勿应助】关于scihub 10000
The Mother of All Tableaux: Order, Equivalence, and Geometry in the Large-scale Structure of Optimality Theory 3000
Social Research Methods (4th Edition) by Maggie Walter (2019) 2390
A new approach to the extrapolation of accelerated life test data 1000
北师大毕业论文 基于可调谐半导体激光吸收光谱技术泄漏气体检测系统的研究 390
Phylogenetic study of the order Polydesmida (Myriapoda: Diplopoda) 370
Robot-supported joining of reinforcement textiles with one-sided sewing heads 360
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 4009979
求助须知:如何正确求助?哪些是违规求助? 3550041
关于积分的说明 11304472
捐赠科研通 3284482
什么是DOI,文献DOI怎么找? 1810684
邀请新用户注册赠送积分活动 886503
科研通“疑难数据库(出版商)”最低求助积分说明 811412