柚皮素
化学
生物利用度
体内
细胞凋亡
生物相容性
脂质体
药理学
小泡
癌症研究
生物物理学
细胞生物学
生物化学
膜
生物
抗氧化剂
类黄酮
有机化学
生物技术
作者
Suresh Sulekha Dhanisha,Sudarsanan Drishya,Chandrasekharan Guruvayoorappan
出处
期刊:Food Chemistry
[Elsevier BV]
日期:2023-09-13
卷期号:434: 137445-137445
被引量:9
标识
DOI:10.1016/j.foodchem.2023.137445
摘要
Naringenin (NG) belongs to the class of flavanones having impressive pharmacological properties. Unfortunately, the in vivo bioavailability of NG is very low due to its higher hydrophobicity, which limits its practical use. Thus, in this study, we tried to develop NG-loaded macrophage membrane-coated liposome-based biomimetic nanoparticles with distinct physicochemical compositions and biological attributes for improving their bioavailability at the target site. The developed biomimetic nanoparticle (BNP) has shown good biocompatibility, stability, satisfactory particle size, pH-responsive drug (NG) release kinetics, and higher cellular uptake in vitro. The anti-metastatic efficacy of NGBNP has confirmed in syngeneic athymic BALB/c nude experimental models. By western blot analysis, semi-quantitative PCR, real-time PCR, and IHC, we conclude that NGBNP gets localized on the metastatic niche via its surface receptor α4, β1 integrin, and VCAM1 of metastatic cells and reduces the number of metastatic colonies in the lungs via regulating the apoptotic signaling axis.
科研通智能强力驱动
Strongly Powered by AbleSci AI