福克斯O1
PDX1型
蛋白激酶B
内分泌学
内科学
PI3K/AKT/mTOR通路
生物
信号转导
血管紧张素II
LY294002型
小岛
化学
胰岛素
细胞生物学
医学
血压
作者
Hao Guo,Dandan Guo,Min An,Ruonan Zhang,Caixia Wang,Junhua He
出处
期刊：Protein and Peptide Letters
[Bentham Science]
日期：2023-11-10
卷期号：30 (12): 1009-1019
标识
DOI：10.2174/0109298665257646231020054036
摘要
Islet β-cell dedifferentiation may be the main cause of reduced insulin secretion. Angiotensin-(1-7) [Ang-(1-7)] can attenuate high glucose-induced apoptosis and dedifferentiation of pancreatic β-cell, but the specific signal transduction pathway and mechanism are not yet clear.
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