Device-measured stationary behaviour and cardiovascular and orthostatic circulatory disease incidence

直立生命体征 医学 循环系统 心脏病学 比例危险模型 内科学 危险系数 血压 置信区间 病理
作者
Matthew Ahmadi,Pieter Coenen,Leon Straker,Emmanuel Stamatakis
出处
期刊:International Journal of Epidemiology [Oxford University Press]
卷期号:53 (6)
标识
DOI:10.1093/ije/dyae136
摘要

Abstract Background Previous studies have indicated that standing may be beneficially associated with surrogate metabolic markers, whereas more time spent sitting has an adverse association. Studies assessing the dose-response associations of standing, sitting and composite stationary behaviour time with cardiovascular disease (CVD) and orthostatic circulatory disease are scarce and show an unclear picture. Objective To examine associations of daily sitting, standing and stationary time with CVD and orthostatic circulatory disease incidence Methods We used accelerometer data from 83 013 adults (mean age ± standard deviation = 61.3 ± 7.8; female = 55.6%) from the UK Biobank to assess daily time spent sitting and standing. Major CVD was defined as coronary heart disease, heart failure and stroke. Orthostatic circulatory disease was defined as orthostatic hypotension, varicose vein, chronic venous insufficiency and venous ulcers. To estimate the dose-response hazard ratios (HR) we used Cox proportional hazards regression models and restricted cubic splines. The Fine–Gray subdistribution method was used to account for competing risks. Results During 6.9 (±0.9) years of follow-up, 6829 CVD and 2042 orthostatic circulatory disease events occurred. When stationary time exceeded 12 h/day, orthostatic circulatory disease risk was higher by an average HR (95% confidence interval) of 0.22 (0.16, 0.29) per hour. Every additional hour above 10 h/day of sitting was associated with a 0.26 (0.18, 0.36) higher risk. Standing more than 2 h/day was associated with an 0.11 (0.05, 0.18) higher risk for every additional 30 min/day. For major CVD, when stationary time exceeded 12 h/day, risk was higher by an average of 0.13 (0.10, 0.16) per hour. Sitting time was associated with a 0.15 (0.11, 0.19) higher risk per extra hour. Time spent standing was not associated with major CVD risk. Conclusions Time spent standing was not associated with CVD risk but was associated with higher orthostatic circulatory disease risk. Time spent sitting above 10 h/day was associated with both higher orthostatic circulatory disease and major CVD risk. The deleterious associations of overall stationary time were primarily driven by sitting. Collectively, our findings indicate increasing standing time as a prescription may not lower major CVD risk and may lead to higher orthostatic circulatory disease risk.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
充电宝应助LT采纳,获得10
刚刚
1秒前
英俊的铭应助zcydbttj2011采纳,获得10
3秒前
明理的音响关注了科研通微信公众号
3秒前
3秒前
tp040900完成签到 ,获得积分10
3秒前
4秒前
kobe完成签到,获得积分10
5秒前
YYL发布了新的文献求助30
5秒前
张三坟应助ccc采纳,获得30
6秒前
lx完成签到,获得积分10
6秒前
山川遇月色完成签到,获得积分10
7秒前
睿子发布了新的文献求助10
7秒前
8秒前
DrCuiTianjin完成签到 ,获得积分10
9秒前
不成安火完成签到,获得积分10
10秒前
CodeCraft应助刻苦海豚采纳,获得10
11秒前
不懈奋进应助shentaii采纳,获得30
11秒前
嗯哼应助山川遇月色采纳,获得20
12秒前
栀子新苷完成签到,获得积分20
14秒前
14秒前
15秒前
16秒前
思源应助finger采纳,获得10
17秒前
斯文败类应助舒心冷松采纳,获得10
18秒前
ccc完成签到,获得积分10
18秒前
燕儿应助Felix采纳,获得10
19秒前
19秒前
Lj发布了新的文献求助10
21秒前
21秒前
WC241002292完成签到,获得积分10
23秒前
030完成签到,获得积分20
25秒前
Jackie完成签到 ,获得积分10
27秒前
30秒前
boya完成签到 ,获得积分10
30秒前
31秒前
Zed发布了新的文献求助20
31秒前
cccccc完成签到,获得积分10
31秒前
Lj完成签到,获得积分10
32秒前
33秒前
高分求助中
좌파는 어떻게 좌파가 됐나:한국 급진노동운동의 형성과 궤적 2500
Sustainability in Tides Chemistry 1500
TM 5-855-1(Fundamentals of protective design for conventional weapons) 1000
Cognitive linguistics critical concepts in linguistics 800
Threaded Harmony: A Sustainable Approach to Fashion 799
Livre et militantisme : La Cité éditeur 1958-1967 500
氟盐冷却高温堆非能动余热排出性能及安全分析研究 500
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 催化作用 物理化学 免疫学 量子力学 细胞生物学
热门帖子
关注 科研通微信公众号,转发送积分 3050909
求助须知:如何正确求助?哪些是违规求助? 2708236
关于积分的说明 7412010
捐赠科研通 2352411
什么是DOI,文献DOI怎么找? 1245174
科研通“疑难数据库(出版商)”最低求助积分说明 605463
版权声明 595796