T细胞受体
多样性(政治)
癌症
生物
计算生物学
地理
医学
内科学
政治学
免疫学
T细胞
免疫系统
法学
作者
Xiaoqing Yu,Li Song,Ling Cen,Biwei Cao,Randa Tao,Yuanyuan Shen,Daniel Abate‐Daga,Paulo C. Rodríguez,José R. Conejo-García,Xuefeng Wang
标识
DOI:10.1016/j.xcrm.2024.101764
摘要
Gamma-delta T cells (γδ T cells) play a crucial role in both innate and adaptive immunity within tumors, yet their presence and prognostic value in cancer remain underexplored. This study presents a large-scale analysis of γδ T cell receptor (γδ TCR) reads from 11,000 tumor samples spanning 33 cancer types, utilizing the TRUST4 algorithm. Our findings reveal extensive diversity in γδ TCR clonality and gene expression, underscoring the potential of γδ T cells as prognostic biomarkers in various cancers. We further demonstrate the utility of TCR gamma (TRG) and delta (TRD) gene expression from standard RNA-sequencing (RNA-seq) data. This comprehensive dataset offers a valuable resource for advancing γδ T cell research, with implications for enhanced immunotherapy approaches or alternative therapeutic strategies. Additionally, our centralized database supports translational research into the therapeutic significance of γδ T cells.
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