生发中心
断点群集区域
选择(遗传算法)
生物
免疫学
B细胞
癌症研究
遗传学
抗体
受体
计算机科学
人工智能
作者
Takeshi Inoue,Yoshihiro Baba,Tomohiro Kurosaki
出处
期刊:PubMed
日期:2024-08-20
标识
DOI:10.1016/j.it.2024.07.005
摘要
When mature B cells are activated by antigens, the selection of these activated B cells takes place particularly during T cell-dependent immune responses in which an improved antibody repertoire is generated through somatic hypermutation in germinal centers (GCs). In this process the importance of antigen presentation by GC B cells, and subsequent T follicular helper (Tfh) cell help in positive selection of GC B cells, has been well appreciated. By contrast, the role of B cell receptor (BCR) signaling per se remains unclear. Strong experimental support for the involvement of BCR signaling in GC B cell selection has now been provided. Interestingly, these studies suggest that several checkpoints operating through the BCR ensure affinity maturation.
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