Initial Patient Characteristics of TSOG 102: A Multicenter Prospective Registry of Active Surveillance in Patients with Multiple Ground Glass Opacities

四分位间距 医学 磨玻璃样改变 前瞻性队列研究 外科 放射科 内科学 癌症 腺癌
作者
James Huang,Kay See Tan,Nasser K. Altorki,Mara B. Antonoff,Shanda H. Blackmon,Raphael Bueno,Bryan M. Burt,Todd L. Demmy,Nathaniel R. Evans,Laura Donahoe,David H. Harpole,Doraid Jarrar,Benjamin D. Kozower,Michael Lanuti,Moïshe Liberman,Jules Lin,Douglas Z. Liou,Michael J. Liptay,James D. Luketich,Arjun Pennathur,Gerard Petersen,R. Taylor Ripley,Matthew M. Rochefort,Christopher W. Seder,Joseph B. Shrager,Stacey Su,Betty C. Tong,Yaron Shargall,Ara A. Vaporciyan,Thomas K. Waddell,Benny Weksler,Dennis A. Wigle,Sai Yendamuri,David R. Jones
出处
期刊:The Journal of Thoracic and Cardiovascular Surgery [American Association for Thoracic Surgery]
标识
DOI:10.1016/j.jtcvs.2024.09.054
摘要

ObjectivePresentation with multiple ground glass opacities (GGOs) is an increasingly common occurrence, and the optimal management of these lesions is unclear. Active surveillance has been increasingly adopted as a management strategy for other low-grade malignancies. We hypothesized that active surveillance could be a feasible and safe option for patients with multiple GGOs.MethodsPatients with ≥2 GGOs (ground glass predominant, <50% solid, ≤3 cm) were enrolled in a multi-institutional registry and prospectively followed up on active surveillance with computed tomography scans every 6 to 12 months. Each GGO was catalogued and measured individually at each follow-up visit.ResultsTarget accrual was met, with 337 patients from 23 institutions. The mean age was 70 years (interquartile range, 65-77 years), and 74% were women. Most were former (70%) or current (9%) smokers, with a mean exposure of 30 pack-years (interquartile range [IQR], 15-44 pack-years). Half of the patients (51%) had a previous lung cancer, and the majority (86%) were already under surveillance at the time of study entry. The median number of GGOs per patient was 3 (IQR, 2-5), with a total of 1467 GGOs under surveillance. The median GGO size was 0.9 cm (IQR, 0.7-1.3 cm). Most GGOs were 0.5 to 1 cm in size.ConclusionsActive surveillance, rather than immediate intervention, was an acceptable option to patients, and accrual to this registry trial was feasible. Safety endpoints and long-term outcomes will be assessed in the planned 5-year follow-up in accordance with the protocol.Graphical abstract

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