溃疡性结肠炎
微生物群
炎症性肠病
粪便细菌疗法
医学
肠道菌群
粪便
疾病
免疫学
克罗恩病
发病机制
结肠炎
微生物学
生物信息学
内科学
生物
抗生素
艰难梭菌
作者
NULL AUTHOR_ID,NULL AUTHOR_ID,Pierre Ellul
标识
DOI:10.1097/meg.0000000000002818
摘要
The understanding of the potential role of the microbiota in the pathogenesis of inflammatory bowel disease (IBD) is ever-evolving. Traditionally, the management of IBD has involved medical therapy and/or surgical intervention. IBD can be characterized by gut microbiome alterations through various pathological processes. Various studies delve into nontraditional methods such as probiotics and fecal microbiota transplant and their potential therapeutic effects. Fecal microbiota transplant involves the delivery of a balanced composition of gut microorganisms into an affected patient via multiple possible routes and methods, while probiotics consist of live microorganisms given via the oral route. At present, neither method is considered first-line treatment, however, fecal microbiota transplant has shown potential success in inducing and maintaining remission in ulcerative colitis. In a study by Kruis and colleagues, Escherichia coli Nissle 1917 was considered to be equivalent to mesalamine in mild ulcerative colitis. Alteration of the microbiome in the management of Crohn’s disease is less well defined. Furthermore, variation in the clinical usefulness of 5-aminosalicylic acid medication has been attributed, in part, to its acetylation and inactivation by gut microbes. In summary, our understanding of the microbiome’s role is continually advancing, with the possibility of paving the way for personalized medicine based on the microbiome.
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