pH-driven fabrication of a caseinate–pectin polyelectrolyte complex as a promising carrier for lutein and zeaxanthin delivery: Microencapsulation, stability, and sustained release properties

叶黄素 果胶 玉米黄质 聚电解质 化学 制作 化学工程 控制释放 纳米技术 材料科学 食品科学 有机化学 类胡萝卜素 聚合物 医学 替代医学 病理 工程类
作者
Gang Zhang,Yuqian Yan,Linlin He,Xin Qi,Yanna Zhao,Xiao Wang,Min Liu,Zhuang Ding,Zhengping Wang,Paul Van der Meeren
出处
期刊:International Journal of Biological Macromolecules [Elsevier]
卷期号:: 136101-136101
标识
DOI:10.1016/j.ijbiomac.2024.136101
摘要

In this study, caseinate-pectin polyelectrolyte complexes and co-solutions were successfully fabricated at pH 3.0 and 7.0, respectively, to encapsulate bioactive molecules. During the fabrication process, the effect of the sequence in which each component was added on lutein/zeaxanthin (Lut/Zx) complexation with sodium caseinate (NaCas) was investigated. The protective effect of the polyelectrolyte complex and co-solution for Lut/Zx in liquid formulations was compared with that of a binary system containing only caseinate and Lut/Zx. Compared with the binary system, the polyelectrolyte complex at pH 3.0 further enhanced the chemical stability of Lut/Zx during storage, whereas the co-solution at pH 7.0 did not exhibit this ability. Unexpectedly, NaCas-Lut/Zx - pectin (NC-L/Z-P) with a theoretically sandwich structure did not exhibit better protection than NaCas-pectin-Lut/Zx (NC-P-L/Z). Fluorescence quenching spectra revealed that the addition of NaCas to Lut/Zx and ultimately to pectin resulted in the formation of a sandwich structure, which was soon followed by structural rebalancing. Finally, freshly prepared NC-L/Z-P complexes were lyophilized to stabilize their sandwich structure, resulting in improved encapsulation and sustained-release properties compared with those of the dried NC-P-L/Z. These results suggest that protein-polysaccharide complexes, combined with timely dehydration, enhance the combination of Lut/Zx with caseinate, leading to heightened protective effects.

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
1秒前
强强完成签到,获得积分10
3秒前
申申完成签到,获得积分10
3秒前
大聪明应助梅一一采纳,获得10
6秒前
旺大财发布了新的文献求助20
9秒前
潇洒的白凝完成签到,获得积分10
10秒前
susian完成签到,获得积分10
12秒前
13秒前
谢谢完成签到,获得积分10
13秒前
14秒前
雅欣完成签到,获得积分10
14秒前
lijing123完成签到,获得积分10
15秒前
15秒前
16秒前
18秒前
默默柚子完成签到,获得积分10
19秒前
天天快乐应助科研通管家采纳,获得10
20秒前
栗子应助科研通管家采纳,获得10
20秒前
li应助科研通管家采纳,获得20
20秒前
852应助科研通管家采纳,获得10
20秒前
zx发布了新的文献求助10
20秒前
20秒前
qiqi完成签到,获得积分10
20秒前
llk完成签到,获得积分10
21秒前
21秒前
zhang完成签到,获得积分10
21秒前
程勋航发布了新的文献求助10
21秒前
21秒前
22秒前
李爱国应助谢谢采纳,获得10
22秒前
kxdxng完成签到 ,获得积分10
23秒前
瓜瓜发布了新的文献求助10
23秒前
hyx完成签到 ,获得积分10
23秒前
于芋菊举报求助违规成功
25秒前
杀出个黎明举报求助违规成功
25秒前
whatever举报求助违规成功
25秒前
25秒前
26秒前
妄语完成签到 ,获得积分10
26秒前
研友_VZG7GZ应助黑白画采纳,获得10
26秒前
高分求助中
Spray / Wall-interaction Modelling by Dimensionless Data Analysis 2000
Aspects of Babylonian celestial divination: the lunar eclipse tablets of Enūma Anu Enlil 500
Mathematics and Finite Element Discretizations of Incompressible Navier—Stokes Flows 500
2024 Medicinal Chemistry Reviews 400
Dictionary of socialism 350
Mixed-anion Compounds 300
Geochemistry, 2nd Edition 地球化学经典教科书第二版 300
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 催化作用 物理化学 免疫学 量子力学 细胞生物学
热门帖子
关注 科研通微信公众号,转发送积分 3195214
求助须知:如何正确求助?哪些是违规求助? 2844065
关于积分的说明 8048372
捐赠科研通 2508562
什么是DOI,文献DOI怎么找? 1340894
科研通“疑难数据库(出版商)”最低求助积分说明 639065
邀请新用户注册赠送积分活动 608015