pH-driven fabrication of a caseinate–pectin polyelectrolyte complex as a promising carrier for lutein and zeaxanthin delivery: Microencapsulation, stability, and sustained release properties

叶黄素 果胶 玉米黄质 聚电解质 化学 制作 化学工程 控制释放 纳米技术 材料科学 食品科学 有机化学 类胡萝卜素 聚合物 医学 替代医学 病理 工程类
作者
Gang Zhang,Yuqian Yan,Linlin He,Xin Qi,Yanna Zhao,Xiao Wang,Min Liu,Zhuang Ding,Zhengping Wang,Paul Van der Meeren
出处
期刊:International Journal of Biological Macromolecules [Elsevier]
卷期号:: 136101-136101
标识
DOI:10.1016/j.ijbiomac.2024.136101
摘要

In this study, caseinate-pectin polyelectrolyte complexes and co-solutions were successfully fabricated at pH 3.0 and 7.0, respectively, to encapsulate bioactive molecules. During the fabrication process, the effect of the sequence in which each component was added on lutein/zeaxanthin (Lut/Zx) complexation with sodium caseinate (NaCas) was investigated. The protective effect of the polyelectrolyte complex and co-solution for Lut/Zx in liquid formulations was compared with that of a binary system containing only caseinate and Lut/Zx. Compared with the binary system, the polyelectrolyte complex at pH 3.0 further enhanced the chemical stability of Lut/Zx during storage, whereas the co-solution at pH 7.0 did not exhibit this ability. Unexpectedly, NaCas-Lut/Zx - pectin (NC-L/Z-P) with a theoretically sandwich structure did not exhibit better protection than NaCas-pectin-Lut/Zx (NC-P-L/Z). Fluorescence quenching spectra revealed that the addition of NaCas to Lut/Zx and ultimately to pectin resulted in the formation of a sandwich structure, which was soon followed by structural rebalancing. Finally, freshly prepared NC-L/Z-P complexes were lyophilized to stabilize their sandwich structure, resulting in improved encapsulation and sustained-release properties compared with those of the dried NC-P-L/Z. These results suggest that protein-polysaccharide complexes, combined with timely dehydration, enhance the combination of Lut/Zx with caseinate, leading to heightened protective effects.

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
123Y完成签到,获得积分10
1秒前
lx完成签到,获得积分20
1秒前
1秒前
1秒前
1秒前
orange发布了新的文献求助10
2秒前
2秒前
jack完成签到,获得积分10
2秒前
大模型应助多发paper啊采纳,获得10
2秒前
英姑应助心动nofear采纳,获得10
2秒前
4秒前
5秒前
张瀚元完成签到,获得积分20
5秒前
cc完成签到,获得积分10
6秒前
NexusExplorer应助谦让真采纳,获得10
7秒前
琉璃苣发布了新的文献求助10
8秒前
8秒前
典雅的曼冬完成签到,获得积分10
8秒前
打打应助体贴薯片采纳,获得10
10秒前
GL_001完成签到,获得积分20
10秒前
12秒前
12秒前
jeff发布了新的文献求助10
12秒前
12秒前
Ava应助小鱼采纳,获得30
12秒前
烟花应助直率的高烽采纳,获得10
13秒前
迅速的丑完成签到,获得积分10
13秒前
16秒前
16秒前
MoCh完成签到,获得积分10
16秒前
HHHHHJ完成签到,获得积分10
16秒前
18秒前
儒雅的斑马完成签到,获得积分10
18秒前
知了又发布了新的文献求助10
19秒前
丘比特应助琉璃苣采纳,获得10
19秒前
陈尹蓝发布了新的文献求助10
20秒前
unicorn完成签到,获得积分10
20秒前
张益权发布了新的文献求助10
20秒前
21秒前
刘敏发布了新的文献求助10
22秒前
高分求助中
Spray / Wall-interaction Modelling by Dimensionless Data Analysis 2000
Write Like a Chemist: A Guide and Resource (第二版) 600
Mixed-anion Compounds 600
A new species of Velataspis (Hemiptera Coccoidea Diaspididae) from tea in Assam 500
Earth System Geophysics 500
Aspects of Babylonian celestial divination: the lunar eclipse tablets of Enūma Anu Enlil 500
Geochemistry, 2nd Edition 地球化学经典教科书第二版 401
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 催化作用 物理化学 免疫学 量子力学 细胞生物学
热门帖子
关注 科研通微信公众号,转发送积分 3199835
求助须知:如何正确求助?哪些是违规求助? 2849046
关于积分的说明 8068740
捐赠科研通 2513318
什么是DOI,文献DOI怎么找? 1346068
科研通“疑难数据库(出版商)”最低求助积分说明 640167
邀请新用户注册赠送积分活动 609894