Prediction Model of Cervical Lymph Node Metastasis in Papillary Thyroid Carcinoma

医学 接收机工作特性 逻辑回归 甲状腺癌 淋巴结 曲线下面积 转移 内科学 回顾性队列研究 肿瘤科 放射科 颈淋巴结 甲状腺乳突癌 癌症 甲状腺
作者
Huiting Chen,Li Zhu,Yong Zhuang,Xiaojian Ye,Fang Chen,Juanhua Zeng
出处
期刊:Cancer Control [SAGE Publishing]
卷期号:31
标识
DOI:10.1177/10732748241295347
摘要

Background The objective of this study is to develop a predictive model for the assessment of cervical lymph node metastasis risk in papillary thyroid carcinoma (PTC). Methods A retrospective study was conducted on 212 patients with PTC who underwent initial surgical treatment from August 2022 to April 2023 in 2 hospitals. Data were randomly split into 7:3 training-validation sets. Logistic regression was used for feature selection and predictive model creation. Model performance was assessed using receiver operating characteristic (ROC) and calibration curves. Clinical utility was determined using decision curves. Results Among the 212 patients with PTC, 104 cases (49.1%) exhibited cervical lymph node metastasis, while 108 cases (50.9%) did not. Multivariate logistic regression analysis revealed that age (OR = 0.95), FT3 (OR = 0.41), tumor maximum diameter ≥0.9 cm (OR = 1.85), intratumoral microcalcifications (OR = 1.84), and suspicious lymph node on ultrasound (OR = 2.96) were independent risk factors for lymph node metastasis in PTC patients ( P < 0.05). The constructed model for predicting the risk of cervical lymph node metastasis demonstrated a training set ROC curve area under the curve (AUC) of 0.742 (95% CI: 0.664 - 0.821), with a cut-off value of 0.615, specificity of 87.8%, and sensitivity of 51.4%. The validation set exhibited an AUC of 0.648 (95% CI: 0.501 - 0.788), with a cut-off value of 0.644, specificity of 91.2%, and sensitivity of 43.3%. Including the BRAF V600 E mutation did not improve the model’s diagnostic performance significantly. Decision curve analysis indicated clinical feasibility of the model. Conclusion The predictive model developed in this study effectively predicts lymph node metastasis risk in PTC patients by incorporating ultrasound features, demographic characteristics, and serum parameters. However, including the BRAF V600 E mutation does not significantly improve the model’s diagnostic performance.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
4秒前
5秒前
蓬松小面包完成签到 ,获得积分20
6秒前
bkagyin应助大白采纳,获得10
6秒前
6秒前
量子星尘发布了新的文献求助10
7秒前
收集快乐发布了新的文献求助10
8秒前
bsf123完成签到,获得积分10
8秒前
9秒前
DeepLearning发布了新的文献求助10
11秒前
11秒前
科研通AI2S应助细辛采纳,获得10
11秒前
12秒前
12秒前
俭朴依白完成签到,获得积分10
12秒前
ElbingX完成签到,获得积分10
14秒前
暴躁小龙发布了新的文献求助10
15秒前
文档发布了新的文献求助10
16秒前
16秒前
严溯发布了新的文献求助10
17秒前
17秒前
19秒前
momo发布了新的文献求助10
19秒前
不可思宇完成签到,获得积分10
20秒前
20秒前
浩浩发布了新的文献求助10
21秒前
Philip发布了新的文献求助10
22秒前
23秒前
赘婿应助SherlockHe采纳,获得10
23秒前
橘子的角动量完成签到,获得积分10
24秒前
严溯完成签到,获得积分10
25秒前
26秒前
胡航航发布了新的文献求助20
26秒前
雨的痕迹发布了新的文献求助10
27秒前
AnnieSsy完成签到,获得积分10
27秒前
程程发布了新的文献求助10
28秒前
浩浩完成签到,获得积分10
29秒前
朴素的小霸王完成签到 ,获得积分10
31秒前
RESLR发布了新的文献求助20
33秒前
34秒前
高分求助中
A new approach to the extrapolation of accelerated life test data 1000
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
‘Unruly’ Children: Historical Fieldnotes and Learning Morality in a Taiwan Village (New Departures in Anthropology) 400
Indomethacinのヒトにおける経皮吸収 400
Phylogenetic study of the order Polydesmida (Myriapoda: Diplopoda) 370
基于可调谐半导体激光吸收光谱技术泄漏气体检测系统的研究 350
Robot-supported joining of reinforcement textiles with one-sided sewing heads 320
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3989297
求助须知:如何正确求助?哪些是违规求助? 3531418
关于积分的说明 11253893
捐赠科研通 3270097
什么是DOI,文献DOI怎么找? 1804884
邀请新用户注册赠送积分活动 882087
科研通“疑难数据库(出版商)”最低求助积分说明 809158