昼夜节律
PI3K/AKT/mTOR通路
蛋白激酶B
中医药
内分泌学
信号转导
药丸
医学
药理学
神经科学
生物
心理学
生物化学
病理
替代医学
作者
Jian-qin Mao,Li Cheng,Yu-Dan Zhang,Guangjing Xie,Ping Wang
标识
DOI:10.1016/j.jep.2024.118696
摘要
The Chinese formula Guben-Jiannao Ye (GBJNY) formula has a long history of usage in traditional Chinese medicine (TCM) for the treatment of learning and memory disorders as well as senile insomnia. This formulation is derived from Sun Simiao's five tonic pills. Furthermore, modern pharmacological investigations have revealed its ability to improve cognitive impairment and ameliorate sleep-wake circadian rhythm disorders. However, the precise mechanism underlying its efficacy remains elusive.
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