细胞毒性T细胞
生物
细胞生物学
归巢(生物学)
T细胞
表型
自然杀伤性T细胞
舱室(船)
免疫学
淋巴结
CD28
ZAP70型
白细胞介素21
免疫系统
体外
遗传学
地质学
海洋学
基因
生态学
作者
Gonzalo Soto‐Heredero,Manuel M. Gómez de las Heras,Jose Ignacio Escrig,Marı́a Mittelbrunn
出处
期刊:Annual Review of Immunology
[Annual Reviews]
日期:2023-04-26
卷期号:41 (1): 181-205
被引量:15
标识
DOI:10.1146/annurev-immunol-101721-064501
摘要
There is a dramatic remodeling of the T cell compartment during aging. The most notorious changes are the reduction of the naive T cell pool and the accumulation of memory-like T cells. Memory-like T cells in older people acquire a phenotype of terminally differentiated cells, lose the expression of costimulatory molecules, and acquire properties of senescent cells. In this review, we focus on the different subsets of age-associated T cells that accumulate during aging. These subsets include extremely cytotoxic T cells with natural killer properties, exhausted T cells with altered cytokine production, and regulatory T cells that gain proinflammatory features. Importantly, all of these subsets lose their lymph node homing capacity and migrate preferentially to nonlymphoid tissues, where they contribute to tissue deterioration and inflammaging.
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