圆二色性
凝血酶
血小板
化学
立体化学
绝对构型
抑制性突触后电位
血小板聚集
二维核磁共振波谱
生物
神经科学
免疫学
作者
Qiu-Yu Zou,Dao-Ran Pang,Yu-Jie Pei,Yang-Gan Luo,Yong-Xiang Wang,huang hao,Zhixiang Zhu,Hui-Xia Huo,Yunfang Zhao,Pengfei Tu,Jun Li
出处
期刊:Fitoterapia
[Elsevier]
日期:2023-04-11
卷期号:167: 105507-105507
被引量:4
标识
DOI:10.1016/j.fitote.2023.105507
摘要
Eight previously undescribed phenolic compounds, dracoropins A – H (1–8), along with two known analogues (9 and 10) were isolated from the fruits of Daemonorops draco. Four pairs of isomers (1a/1b, 2a/2b, 3a/3b, and 4a/4b) were resolved by using chiral-phase HPLC separation. Their structures, including the absolute configurations of the resolved isomers, were elucidated by analysis of spectroscopic data (1D and 2D NMR, IR, and HRESIMS), single-crystal X-ray diffraction, and electronic circular dichroism (ECD) calculations. Compounds 1, 2, and 3 bear a rare 2-phenylbenzo[d]-1,3-dioxepine skeleton. All the isolates were evaluated for their inhibitory activity against ATP release in thrombin-activated platelets. Compounds 2b, 3a, and 6 could significantly inhibit ATP release in thrombin-activated platelets.
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