The nuclear receptor REV-ERBα integrates circadian clock and energy metabolism.

The physiological processes of mammals show rhythmic changes in a 24-h cycle. Circadian rhythms are under the subtle control of the autonomous circadian clock, and dysregulation of the circadian system can lead to health problems such as metabolic disorders. REV-ERBα, a member of the nuclear receptor superfamily, is an important component of the mammalian circadian clock. REV-ERBα regulates various physiological processes, including the regulation of metabolism, inflammation and immunity as well as the circadian rhythm, making it a potential therapeutic target for metabolic syndrome, inflammatory diseases and cancers. In recent years, an array of new REV-ERBα ligands have been discovered, most of which have potential applications in the treatment of diseases. In this review, we focus on the regulatory role of nuclear receptor REV-ERBα in energy metabolism and inflammation, in order to provide new strategies for the therapy of metabolic syndrome and its related diseases.哺乳动物的各项生理活动以24 h为周期呈现节律性变化。稳定的昼夜节律由生物钟系统所精细调控，而昼夜节律的紊乱会导致代谢性疾病的发生。核受体超家族成员REV-ERBα是哺乳动物生物钟的重要组成部分，参与代谢、炎症、免疫和昼夜节律等多种生理过程的调节，是代谢性疾病、炎症性疾病和癌症的潜在治疗靶点。近年来发现了一系列新的REV-ERBα配体，其中大部分在疾病治疗方面具有潜在的应用价值。本文主要介绍核受体REV-ERBα在能量代谢以及炎症反应中的调节作用，以期为代谢综合征及相关疾病的治疗提供新的策略和参考。.