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Manipulation of Heterogeneous Surface Electric Potential Promotes Osteogenesis by Strengthening RGD Peptide Binding and Cellular Mechanosensing

材料科学 焦点粘着 细胞外基质 纳米技术 机械转化 纤维连接蛋白 生物物理学 纳米纤维 细胞生物学 信号转导 生物
作者
Yunyang Bai,Xiaona Zheng,Xianwei Zhong,Qun Cui,Zhang Shuan,Xiufang Wen,Boon Chin Heng,Shan He,Yang Shen,Jinxing Zhang,Yan Wei,Xuliang Deng,Xuehui Zhang
出处
期刊:Advanced Materials [Wiley]
卷期号:35 (24) 被引量:28
标识
DOI:10.1002/adma.202209769
摘要

Abstract The heterogeneity of extracellular matrix (ECM) topology, stiffness, and architecture is a key factor modulating cellular behavior and osteogenesis. However, the effects of heterogeneous ECM electric potential at the micro‐ and nanoscale on osteogenesis remain to be elucidated. Here, the heterogeneous distribution of surface potential is established by incorporating ferroelectric BaTiO 3 nanofibers (BTNF) into poly(vinylidene fluoridetrifluoroethylene) (P(VDF‐TrFE)) matrix based on phase‐field and first‐principles simulation. By optimizing the aspect ratios of BTNF fillers, the anisotropic distribution of surface potential on BTNF/P(VDF‐TrFE) nanocomposite membranes can be achieved by strong spontaneous electric polarization of BTNF fillers. These results indicate that heterogeneous surface potential distribution leads to a meshwork pattern of fibronectin (FN) aggregation, which increased FN‐III7‐10 (FN fragment) focal flexibility and anchor points as predicted by molecular dynamics simulation. Furthermore, integrin clustering, focal adhesion formation, cell spreading, and adhesion are enhanced sequentially. Increased traction of actin fibers amplifies mechanotransduction by promoting nuclear translocation of YAP/Runx2, which enhances osteogenesis in vitro and bone regeneration in vivo. The work thus provides fundamental insights into the biological effects of surface potential heterogeneity at the micro‐ and nanoscale on osteogenesis, and also develops a new strategy to optimize the performance of electroactive biomaterials for tissue regenerative therapies.
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