Novel clinical associations between time in range and microangiopathies in people with type 2 diabetes mellitus on hemodialysis

医学 糖尿病 微血管病 内科学 糖尿病性视网膜病变 视网膜病变 血糖性 低血糖 1型糖尿病 内分泌学 2型糖尿病 横断面研究 病理
作者
Akinori Hayashi,Naoya Shimizu,Agena Suzuki,Rei Fujishima,Kenta Matoba,Ibuki Moriguchi,Naoyuki Kobayashi,Takeshi Miyatsuka
出处
期刊:Journal of Diabetes and Its Complications [Elsevier BV]
卷期号:37 (5): 108470-108470 被引量:1
标识
DOI:10.1016/j.jdiacomp.2023.108470
摘要

We investigated associations among glucose time in range (TIR, 70-180 mg/dL), glycemic markers and prevalence of diabetic microangiopathy in people with diabetes undergoing hemodialysis (HD).A total of 107 people with type 2 diabetes undergoing HD (HbA1c 6.4 %; glycated albumin [GA] 20.6 %) using continuous glucose monitoring were analyzed in this observational and cross-sectional study.HbA1c and GA levels significantly negatively correlated with TIR, and positively correlated with time rate of hyperglycemia, but not with time rate of hypoglycemia. TIR of 70 % corresponded to HbA1c of 6.5 % and GA of 21.2 %. The estimated HbA1c level corresponding to TIR of 70 % in this study was lower than that previously reported in people with diabetes without HD. The prevalence of diabetic neuropathy was not significantly different between people with TIR ≥ 70 % and those with TIR < 70 % (P = 0.1925), but the prevalence of diabetic retinopathy in people with TIR ≥ 70 % was significantly lower than in those with TIR < 70 % (P = 0.0071).TIR correlated with HbA1c and GA levels in people with type 2 diabetes on HD. Additionally, a higher TIR resulted in a lower rate of diabetic retinopathy.What is already known about this subject? What is the key question? What are the new findings? How might this impact on clinical practice in the foreseeable future?
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