Association of Computed Tomography Radiomics Signature with Progression-free Survival in Neuroblastoma Patients

医学 置信区间 接收机工作特性 无线电技术 一致相关系数 组内相关 一致性 比例危险模型 核医学 统计 放射科 内科学 数学 临床心理学 心理测量学
作者
H Wang,T Li,Mingxing Xie,Jiawen Si,Jing Qin,Yang� Yang,Li Zhang,Hui Ding,Daniel Chen,Ling He
出处
期刊:Clinical Oncology [Elsevier BV]
卷期号:35 (11): e639-e647 被引量:2
标识
DOI:10.1016/j.clon.2023.06.008
摘要

Aims To investigate the association of computed tomography radiomics signature with progression-free survival (PFS) in neuroblastoma patients. Materials and methods We retrospectively included 167 neuroblastoma patients who were divided into a training set and a test set through stratified sampling at a ratio of 7:3. Regions of interest of the primary tumours were delineated on pretreatment contrast-enhanced computed tomography images and radiomics features were extracted from them. The intraclass correlation coefficient, Pearson correlation coefficient, and least absolute shrinkage and selection operator Cox regression algorithm were applied to select radiomics features and construct the radiomics signature. The effectiveness of the signature in predicting PFS was evaluated using the concordance index (C-index) and 95% confidence interval in both the training and the test sets. The time-dependent receiver operator characteristic curve of the radiomics signature was plotted and the area under the curve (AUC) was calculated. A calibration curve was used to assess the difference between the predicted probability of the radiomics signature and the observed probability at different time points. Results The radiomics signature was composed of six features, which achieved a C-index of 0.733 (95% confidence interval 0.664–0.803) in the training set and 0.734 (95% confidence interval 0.608–0.861) in the test set. In the training set, the radiomics signature yielded an AUC of 0.707, 0.737, 0.788, 0.859 and 0.829 for 1-, 2-, 3-, 4- and 5-year PFS, respectively. Similarly, the radiomics signature exhibited an AUC of 0.738, 0.807, 0.761, 0.787 and 0.818 for 1-, 2-, 3-, 4- and 5-year PFS, respectively, in the test set. The calibration curves showed no significant difference between the predicted probability of the radiomics signature and the observed probability for up to 5 years. Conclusions Computed tomography radiomics features exhibit a significant correlation with the PFS of neuroblastoma patients, particularly in terms of long-term outcomes.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
2秒前
3秒前
ZZZ关闭了ZZZ文献求助
3秒前
小小酥被卷了完成签到,获得积分10
6秒前
6秒前
7秒前
8秒前
猪猪hero发布了新的文献求助10
8秒前
东木应助yf采纳,获得100
8秒前
冷艳的道天完成签到 ,获得积分10
10秒前
追晚风的人完成签到 ,获得积分10
11秒前
11秒前
暖暖圆圆完成签到 ,获得积分10
11秒前
11秒前
花花发布了新的文献求助10
12秒前
12秒前
gar发布了新的文献求助10
12秒前
无限的山水完成签到 ,获得积分10
13秒前
炎炎夏无声完成签到 ,获得积分10
14秒前
CHSLN完成签到 ,获得积分10
15秒前
liu发布了新的文献求助10
16秒前
17秒前
17秒前
小穆完成签到,获得积分10
18秒前
ratziel发布了新的文献求助10
18秒前
vin应助rita_sun1969采纳,获得40
18秒前
坚定的慕卉完成签到,获得积分10
18秒前
Lucas应助眼睛大尔白采纳,获得10
18秒前
cdercder发布了新的文献求助10
21秒前
持满发布了新的文献求助10
21秒前
科研通AI5应助没有昵称采纳,获得10
22秒前
怡然的乘风完成签到 ,获得积分10
22秒前
CV16完成签到,获得积分10
24秒前
Ren应助宋晓静采纳,获得10
25秒前
浮浮沉沉发布了新的文献求助10
25秒前
27秒前
fei完成签到,获得积分10
27秒前
Toong完成签到,获得积分10
29秒前
29秒前
29秒前
高分求助中
A new approach to the extrapolation of accelerated life test data 1000
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
‘Unruly’ Children: Historical Fieldnotes and Learning Morality in a Taiwan Village (New Departures in Anthropology) 400
Indomethacinのヒトにおける経皮吸収 400
Phylogenetic study of the order Polydesmida (Myriapoda: Diplopoda) 370
基于可调谐半导体激光吸收光谱技术泄漏气体检测系统的研究 350
Robot-supported joining of reinforcement textiles with one-sided sewing heads 320
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3988827
求助须知:如何正确求助?哪些是违规求助? 3531183
关于积分的说明 11252671
捐赠科研通 3269809
什么是DOI,文献DOI怎么找? 1804780
邀请新用户注册赠送积分活动 881885
科研通“疑难数据库(出版商)”最低求助积分说明 809021