清晨好,您是今天最早来到科研通的研友!由于当前在线用户较少,发布求助请尽量完整地填写文献信息,科研通机器人24小时在线,伴您科研之路漫漫前行!

Accelerometer-measured intensity-specific physical activity, genetic risk and incident type 2 diabetes: a prospective cohort study

医学 前瞻性队列研究 比例危险模型 队列 内科学 队列研究 入射(几何) 代谢当量 2型糖尿病 强度(物理) 糖尿病 危险系数 人口学 体力活动 物理疗法 置信区间 内分泌学 社会学 物理 光学 量子力学
作者
Mengyun Luo,Chenhao Yu,Borja del Pozo Cruz,Liangkai Chen,Ding Ding
出处
期刊:British Journal of Sports Medicine [BMJ]
卷期号:57 (19): 1257-1264 被引量:5
标识
DOI:10.1136/bjsports-2022-106653
摘要

Although 30 min/day of moderate-intensity physical activity is suggested for preventing type 2 diabetes (T2D), the current recommendations exclusively rely on self-reports and rarely consider the genetic risk. We examined the prospective dose-response relationships between total/intensity-specific physical activity and incident T2D accounting for and stratified by different levels of genetic risk.This prospective cohort study was based on 59 325 participants in the UK Biobank (mean age=61.1 years in 2013-2015). Total/intensity-specific physical activity was collected using accelerometers and linked to national registries until 30 September 2021. We examined the shape of the dose-response association between physical activity and T2D incidence using restricted cubic splines adjusted for and stratified by a polygenic risk score (based on 424 selected single nucleotide polymorphisms) using Cox proportional hazards models.During a median follow-up of 6.8 years, there was a strong linear dose-response association between moderate-to-vigorous-intensity physical activity (MVPA) and incident T2D, even after adjusting for genetic risk. Compared with the least active participants, the HRs (95% CI) for higher levels of MVPA were: 0.63 (0.53 to 0.75) for 5.3-25.9 min/day, 0.41 (0.34 to 0.51) for 26.0-68.4 min/day and 0.26 (0.18 to 0.38) for >68.4 min/day. While no significant multiplicative interaction between physical activity measures and genetic risk was found, we found a significant additive interaction between MVPA and genetic risk score, suggesting larger absolute risk differences by MVPA levels among those with higher genetic risk.Participation in physical activity, particularly MVPA, should be promoted especially in those with high genetic risk of T2D. There may be no minimal or maximal threshold for the benefits. This finding can inform future guidelines development and interventions to prevent T2D.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
沐浠完成签到 ,获得积分10
13秒前
葛力完成签到,获得积分20
17秒前
科研通AI2S应助葛力采纳,获得10
29秒前
30秒前
宇文非笑完成签到 ,获得积分0
38秒前
科研通AI5应助laodai8855采纳,获得20
39秒前
41秒前
乾坤侠客LW完成签到,获得积分10
1分钟前
1分钟前
lixuebin完成签到 ,获得积分10
2分钟前
科研通AI2S应助葛力采纳,获得10
2分钟前
lxh完成签到 ,获得积分10
2分钟前
2分钟前
2分钟前
laodai8855发布了新的文献求助20
2分钟前
3分钟前
3分钟前
科研通AI5应助梨子茶采纳,获得30
3分钟前
3分钟前
bju发布了新的文献求助10
3分钟前
3分钟前
科研通AI2S应助科研通管家采纳,获得10
3分钟前
搜集达人应助科研通管家采纳,获得10
3分钟前
科研通AI2S应助科研通管家采纳,获得10
3分钟前
bju完成签到,获得积分10
3分钟前
4分钟前
梨子茶发布了新的文献求助30
4分钟前
mczhu完成签到,获得积分10
4分钟前
聪慧芷巧完成签到 ,获得积分10
4分钟前
qqJing完成签到,获得积分10
4分钟前
deallyxyz应助草木采纳,获得10
4分钟前
5分钟前
5分钟前
常有李完成签到,获得积分10
5分钟前
5分钟前
默默孱完成签到 ,获得积分10
5分钟前
JamesPei应助汎影采纳,获得10
5分钟前
5分钟前
Lucas应助汎影采纳,获得10
5分钟前
wwe完成签到,获得积分10
5分钟前
高分求助中
A new approach to the extrapolation of accelerated life test data 1000
Cognitive Neuroscience: The Biology of the Mind 1000
Technical Brochure TB 814: LPIT applications in HV gas insulated switchgear 1000
Immigrant Incorporation in East Asian Democracies 600
Nucleophilic substitution in azasydnone-modified dinitroanisoles 500
不知道标题是什么 500
A Preliminary Study on Correlation Between Independent Components of Facial Thermal Images and Subjective Assessment of Chronic Stress 500
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3968504
求助须知:如何正确求助?哪些是违规求助? 3513318
关于积分的说明 11167279
捐赠科研通 3248691
什么是DOI,文献DOI怎么找? 1794414
邀请新用户注册赠送积分活动 875030
科研通“疑难数据库(出版商)”最低求助积分说明 804652