Abstract Benzopyran derivatives are essential for life and are found abundantly in nature. Benzopyran compounds and their derivatives play an essential role in medicinal chemistry. The alkaloids, flavonoids, tocopherols, and anthocyanins natural products comprise benzopyran's basic structure. Various benzopyran derivatives have been used for therapeutic effects. Benzopyran derivatives can be proficient in various pharmaceutical applications for cellular markers. The basic structure of benzopyran is an efficient class of synthetic products and an emerging attention area of research. Therefore, impactful information on benzopyran and its derivatives has been compiled in the last several years. Recently, the development of novel benzopyran and its applications are contributing to medicines and pharmacy.