Is There a Link Between Non-Alcoholic Fatty Liver Disease and Benign Prostate Hyperplasia/Lower Urinary Tract Symptoms: A Systematic Review and a Meta-Analysis

医学 下尿路症状 荟萃分析 科克伦图书馆 前列腺 国际前列腺症状评分 脂肪肝 非酒精性脂肪肝 增生 内科学 泌尿科 前列腺癌 梅德林 系统回顾 疾病 胃肠病学 癌症 法学 政治学
作者
Hüseyin Beşiroğlu,Mustafa Kadıhasanoğlu
出处
期刊:Metabolic Syndrome and Related Disorders [Mary Ann Liebert]
卷期号:21 (7): 370-377 被引量:1
标识
DOI:10.1089/met.2023.0013
摘要

Background: Prostatic growth has been thought to be the systemic manifestation of some metabolic derangements in recent studies. Nonalcoholic fatty liver disease (NAFLD), a hepatic manifestation of the metabolic syndrome, might be closely linked with benign prostate hyperplasia and lower urinary tract symptoms (BPH/LUTS). Several studies have been conducted regarding NAFLD and BPH/LUTS association. However, the results are yet to reach a clear conclusion. We aimed to gather these studies' results to make a more robust analysis through a systematic review and meta-analysis. Methods: We systematically searched Pubmed-Medline, Cochrane Library, and Science Direct databases. We excluded all experimental studies, case reports, and reviews. Our search was restricted to the English language. We used standard mean difference for BPH/LUTS-related parameters. We identified the study qualities by the Newcastle-Ottawa Scale. We conducted a publication bias analysis. Results: A total of six studies involving 7089 participants fulfilled the inclusion criteria. Our meta-analysis revealed that patients with NAFLD have larger prostate volume [0.553 (0.303-0.802), P ˂ 0.001; Q = 97.41; P-value for heterogeneity = P < 0.0001; I2 = 94.86%]. However, the summary effect size of the other parameters of BPH/LUTS (prostate-specific antigen and international prostate symptom score) computed in our meta-analysis did not yield significant results. Conclusions: The prostate size was larger in patients with NAFLD, but the meta-analysis did not reach a significant result for LUTS among the studies. These results should be tested with well-designed studies, in particular, to clarify the association of LUTS with NAFLD.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
SICHEN发布了新的文献求助20
1秒前
陈平安发布了新的文献求助10
1秒前
复杂向彤关注了科研通微信公众号
2秒前
liian7应助xiaozeng采纳,获得60
3秒前
文敏完成签到,获得积分10
4秒前
晚街听风完成签到 ,获得积分10
6秒前
桐桐应助nuannuan采纳,获得10
7秒前
天天快乐应助贺雪采纳,获得10
10秒前
Vivian完成签到 ,获得积分10
10秒前
12秒前
科研通AI2S应助酷炫思天采纳,获得10
13秒前
星空下的皮先生完成签到,获得积分10
13秒前
cuduoduo发布了新的文献求助10
14秒前
在水一方应助王金娥采纳,获得10
14秒前
15秒前
SICHEN发布了新的文献求助20
17秒前
17秒前
机灵夏云完成签到,获得积分10
18秒前
SN应助科研通管家采纳,获得10
19秒前
CodeCraft应助科研通管家采纳,获得10
19秒前
小马甲应助科研通管家采纳,获得10
19秒前
天天快乐应助科研通管家采纳,获得10
19秒前
隐形曼青应助科研通管家采纳,获得10
19秒前
脑洞疼应助科研通管家采纳,获得10
19秒前
斯文败类应助科研通管家采纳,获得10
20秒前
JamesPei应助科研通管家采纳,获得10
20秒前
Jasper应助科研通管家采纳,获得10
20秒前
英姑应助科研通管家采纳,获得10
20秒前
研友_VZG7GZ应助科研通管家采纳,获得10
20秒前
20秒前
22秒前
24秒前
贺雪发布了新的文献求助10
27秒前
27秒前
肥波发布了新的文献求助20
27秒前
27秒前
燕儿完成签到,获得积分10
28秒前
风评完成签到,获得积分10
29秒前
29秒前
酷炫思天发布了新的文献求助10
30秒前
高分求助中
Evolution 10000
ISSN 2159-8274 EISSN 2159-8290 1000
Becoming: An Introduction to Jung's Concept of Individuation 600
Ore genesis in the Zambian Copperbelt with particular reference to the northern sector of the Chambishi basin 500
A new species of Coccus (Homoptera: Coccoidea) from Malawi 500
A new species of Velataspis (Hemiptera Coccoidea Diaspididae) from tea in Assam 500
PraxisRatgeber: Mantiden: Faszinierende Lauerjäger 500
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 催化作用 物理化学 免疫学 量子力学 细胞生物学
热门帖子
关注 科研通微信公众号,转发送积分 3161006
求助须知:如何正确求助?哪些是违规求助? 2812229
关于积分的说明 7895058
捐赠科研通 2471142
什么是DOI,文献DOI怎么找? 1315908
科研通“疑难数据库(出版商)”最低求助积分说明 631069
版权声明 602086