已入深夜,您辛苦了!由于当前在线用户较少,发布求助请尽量完整的填写文献信息,科研通机器人24小时在线,伴您度过漫漫科研夜!祝你早点完成任务,早点休息,好梦!

Protective Effects of Imeglimin and Metformin Combination Therapy on β-Cells in db/db Male Mice

二甲双胍 内分泌学 内科学 细胞凋亡 脂肪组织 胰岛素 人口 生物 医学 生物化学 环境卫生
作者
Kuniyuki Nishiyama,Masato Ono,Takahiro Tsuno,Ryota Inoue,Ayako Fukunaka,Tomoko Okuyama,Mayu Kyohara,Yuichi Togashi,Setsuko Fukushima,Tatsuya Atsumi,Aoi Sato,Akihisa Tsurumoto,Chiaki Sakai,Yoshio Fujitani,Yasuo Terauchi,Shuichi Ito,Jun Shirakawa
出处
期刊:Endocrinology [The Endocrine Society]
卷期号:164 (8) 被引量:4
标识
DOI:10.1210/endocr/bqad095
摘要

Imeglimin and metformin act in metabolic organs, including β-cells, via different mechanisms. In the present study, we investigated the impacts of imeglimin, metformin, or their combination (Imeg + Met) on β-cells, the liver, and adipose tissues in db/db mice. Imeglimin, metformin, or Imeg + Met treatment had no significant effects on glucose tolerance, insulin sensitivity, respiratory exchange ratio, or locomotor activity in db/db mice. The responsiveness of insulin secretion to glucose was recovered by Imeg + Met treatment. Furthermore, Imeg + Met treatment increased β-cell mass by enhancing β-cell proliferation and ameliorating β-cell apoptosis in db/db mice. Hepatic steatosis, the morphology of adipocytes, adiposity assessed by computed tomography, and the expression of genes related to glucose or lipid metabolism and inflammation in the liver and fat tissues showed no notable differences in db/db mice. Global gene expression analysis of isolated islets indicated that the genes related to regulation of cell population proliferation and negative regulation of cell death were enriched by Imeg + Met treatment in db/db islets. In vitro culture experiments confirmed the protective effects of Imeg + Met against β-cell apoptosis. The expression of Snai1, Tnfrsf18, Pdcd1, Mmp9, Ccr7, Egr3, and Cxcl12, some of which have been linked to apoptosis, in db/db islets was attenuated by Imeg + Met. Treatment of a β-cell line with Imeg + Met prevented apoptosis induced by hydrogen peroxide or palmitate. Thus, the combination of imeglimin and metformin is beneficial for the maintenance of β-cell mass in db/db mice, probably through direct action on β-cells, suggesting a potential strategy for protecting β-cells in the treatment of type 2 diabetes.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
Bey完成签到,获得积分10
2秒前
3秒前
我是老大应助zzz采纳,获得10
3秒前
cc关闭了cc文献求助
5秒前
yy122完成签到,获得积分10
6秒前
7秒前
甜甜完成签到 ,获得积分10
7秒前
圆圆圆完成签到 ,获得积分10
8秒前
GT完成签到,获得积分10
9秒前
小王完成签到 ,获得积分10
9秒前
hoongyan完成签到 ,获得积分10
11秒前
Wei完成签到 ,获得积分10
11秒前
于夏旋完成签到,获得积分10
12秒前
12秒前
JamesPei应助天选之子采纳,获得10
13秒前
完美世界应助迷人羊采纳,获得10
13秒前
13秒前
14秒前
酒醉的蝴蝶完成签到 ,获得积分10
14秒前
ZhaoY完成签到,获得积分10
16秒前
冯婷完成签到 ,获得积分10
17秒前
孤独的采珊完成签到 ,获得积分10
17秒前
搜集达人应助圣洁采纳,获得10
17秒前
诺诺发布了新的文献求助10
18秒前
zzuzll完成签到,获得积分10
19秒前
大傻春发布了新的文献求助10
19秒前
又一颗栗子完成签到,获得积分20
20秒前
lpc发布了新的文献求助10
21秒前
不能随便完成签到,获得积分10
23秒前
Akim应助义气代梅采纳,获得10
23秒前
冷静的寒荷完成签到 ,获得积分10
23秒前
汉堡包应助顺利毕业采纳,获得10
27秒前
27秒前
莫言完成签到,获得积分10
27秒前
28秒前
28秒前
硫酸二铵合银完成签到,获得积分10
28秒前
momo完成签到,获得积分10
29秒前
Bruce发布了新的文献求助10
31秒前
31秒前
高分求助中
中国国际图书贸易总公司40周年纪念文集 大事记1949-1987 2000
TM 5-855-1(Fundamentals of protective design for conventional weapons) 1000
草地生态学 880
Threaded Harmony: A Sustainable Approach to Fashion 799
Basic Modern Theory of Linear Complex Analytic 𝑞-Difference Equations 510
Queer Politics in Times of New Authoritarianisms: Popular Culture in South Asia 500
Livre et militantisme : La Cité éditeur 1958-1967 500
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 催化作用 物理化学 免疫学 量子力学 细胞生物学
热门帖子
关注 科研通微信公众号,转发送积分 3059398
求助须知:如何正确求助?哪些是违规求助? 2715371
关于积分的说明 7444724
捐赠科研通 2360874
什么是DOI,文献DOI怎么找? 1251017
科研通“疑难数据库(出版商)”最低求助积分说明 607671
版权声明 596448