医学
哮喘
肿瘤坏死因子α
病理生理学
哮喘的病理生理学
白细胞介素
细胞因子
免疫学
内科学
作者
Muhammad Adrish,Praveen Akuthota
标识
DOI:10.1016/j.rmed.2023.107327
摘要
•There is no globally accepted definition of non-T2 asthma which has been identified in studies by absence of T2-high markers. •Pathophysiology of neutrophilic asthma is poorly understood with possible role of type-1 and type-17 helper cells. •Cytokines including interleukin (IL)-17, IL-6, IL-8, IL-1β, tumor necrosis factor and interferon gamma may also play a role. •Azithromycin and Tezepelumab are the currently available therapies for patients with non-T2 asthma. •Imatinib and clazakizumab are being actively studied for this indication.
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