Acylated secoiridoid glucosides isolated from the fruit extract of Symplocos lucida inhibit β-glucuronidase

Two new acylated secoiridoid glucosides, designated symplolucidins A and B, were isolated from the fruit extract of Symplocos lucida (Thunb.) Siebold & Zucc. Their structures, including their absolute configurations, were elucidated by extensive spectroscopic analyses and chemical reactions. They were found to exhibit β-glucuronidase inhibitory effect. • Two new secoiridoid glucosides were isolated from the fruits of Symplocos lucida. • The structures were characterized by spectroscopic methods. • β-Glucuronidase inhibitory activity was evaluated.