热休克蛋白70
下调和上调
幽门螺杆菌
热休克蛋白
胃
体内
胃肠道
刺激
材料科学
化学
生物
医学
内科学
生物化学
基因
生物技术
作者
Xin Xia,Zhiwei Yin,Yanxia Yang,Shengkai Li,Linlin Wang,Xinqi Cai,Yiting Xu,Chao Ma,Ye Qiu,Zhuo Chen,Weihong Tan
出处
期刊:ACS Nano
[American Chemical Society]
日期:2022-08-22
卷期号:16 (9): 14043-14054
被引量:10
标识
DOI:10.1021/acsnano.2c03911
摘要
Taking inspiration from the mechanism of Helicobacter pylori infection can lead to innovative antibacterial ways to fight antibiotics resistance. Herein, a gastric nano-heater iron–cobalt alloy shielded with graphitic shells (FeCo@G) is developed to interfere with H. pylori infection under an alternating magnetic field. FeCo@G shows a high and stable specific loss power (SLP = 534.1 W g-1) in the acidic environment and provides efficient magnetothermal stimulation in the stomach. Such stimulation upregulates the cytoprotective heat shock protein 70 (HSP70) in gastric epithelial cells, which antagonizes the infection of H. pylori. This finding is further supported by the transcriptomic analysis verifying the upregulation of HSP70 in the stomach. Moreover, the nano-heater shows a high inhibition rate of H. pylori in vivo with good biocompatibility; 95% of FeCo@G is excreted from the mouse's gastrointestinal tract within 12 h. In summary, FeCo@G allows magnetothermal therapy to be used in harsh gastric environments, providing an approach for the therapy against H. pylori.
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