Myocardial Uptake of 68Ga-Pentixafor in a Patient With Systemic Amyloidosis

Abstract A 55-year-old man presented with chest tightness and lower-limb edema for 1 year. Laboratory and imaging examinations suggested cardiac amyloidosis. Both 18 F-FDG and 68 Ga-pentixafor PET/CT showed increased uptake in the myocardium of the left ventricle, whereas the bone marrow had diffusely mild uptake of 68 Ga-pentixafor without bone destruction. 99m Tc-MDP bone scintigraphy also detected extraosseous uptake in the heart, gut, kidneys, and soft tissue. The biopsy of the abdominal subcutaneous fat confirmed amyloid deposits, and the patient was finally diagnosed with primary systemic amyloidosis. This case demonstrated that cardiac amyloidosis might show increased 68 Ga-pentixafor uptake in myocardium.