中子俘获
DNA损伤
放射化学
线性能量转移
硼
中子温度
中子
相对生物效应
辐照
带电粒子
DNA
辐射损伤
化学
材料科学
核物理学
物理
生物化学
离子
有机化学
出处
期刊:The Enzymes
日期:2022-01-01
卷期号:: 65-78
被引量:8
标识
DOI:10.1016/bs.enz.2022.08.005
摘要
Boron Neutron Capture Therapy (BNCT) is a tumor cell selective high LET (linear energy transfer) particle beam therapy. The patient is administrated a boron (10B) compound via intravenous injection or infusion, and when 10B is sufficiently accumulated in the tumor, neutron beams containing epithermal neutrons as the main component are irradiated. Epithermal neutrons lose energy in the body and become thermal neutrons. The captured 10B undergoes a (n, α) reaction with thermal neutrons, and the resulting α particles and 7Li nuclei have short ranges of 9–10 μm and 4–5 μm, respectively, and do not reach the surrounding cells in normal tissues. Therefore, these high LET—heavy charged particles can selectively kill cancer cells. The cell-killing effect of these heavy charged particles is thought to be triggered by DNA damage. It is known that DNA damage caused by heavy charged particles is more serious and difficult to repair than DNA damage caused by Low LET radiation such as X-rays and γ-rays. This review focuses on DNA damage, e.g., DNA strand breaks and DNA damage repair caused by BNCT and describes the resulting biological response.
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