光异构化
化学
生物物理学
锌
微管
微管聚合
聚合
高分子化学
微管蛋白
细胞生物学
有机化学
生物
聚合物
异构化
催化作用
作者
Fengshu Cao,Haobing Wang,Nong Lu,Pingyu Zhang,Huaiyi Huang
标识
DOI:10.1002/anie.202301344
摘要
The photoisomerization-induced cytotoxicity in photopharmacology provides a unique pathway for phototherapy because it is independent of endogenous oxygen. In this study, we developed a biosafe photoisomerizable zinc(II) complex (Zn1), which releases its trans ligand (trans-L1) after being irradiated with blue light. This causes the complex to undergo photoisomerization and produce the toxic cis product (cis-L1) and generate singlet oxygen (1 O2 ). The resulting series of events caused impressive phototoxicity in hypoxic A431 skin cancer cells, as well as in a tumor model in vivo. Interestingly, Zn1 was able to inhibit tumor microtubule polymerization, while still showing good biocompatibility and biosafety in vivo. This photoisomerizable zinc(II) complex provides a novel strategy for addressing the oxygen-dependent limitation of traditional photodynamic therapy.
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