染色质
染色质重塑
嘉雅宠物
分区(防火)
二价染色质
支架/基质附着区域
组蛋白修饰酶
细胞生物学
核心
染色质结构重塑复合物
生物
遗传学
DNA
生物化学
酶
作者
Xiaoli Li,Ziyang An,Wenqing Zhang,Feifei Li
出处
期刊:Genes
[MDPI AG]
日期:2023-02-15
卷期号:14 (2): 499-499
被引量:8
标识
DOI:10.3390/genes14020499
摘要
The multi-level spatial chromatin organization in the nucleus is closely related to chromatin activity. The mechanism of chromatin organization and remodeling attract much attention. Phase separation describes the biomolecular condensation which is the basis for membraneless compartments in cells. Recent research shows that phase separation is a key aspect to drive high-order chromatin structure and remodeling. In addition, chromatin functional compartmentalization in the nucleus which is formed by phase separation also plays an important role in overall chromatin structure. In this review, we summarized the latest work about the role of phase separation in spatial chromatin organization, focusing on direct and indirect effects of phase separation on 3D chromatin organization and its impact on transcription regulation.
科研通智能强力驱动
Strongly Powered by AbleSci AI