抗菌剂
青枯菌
抗菌活性
金黄色葡萄球菌
表皮葡萄球菌
细菌
化学
芽孢杆菌(形态)
IC50型
最小抑制浓度
微生物学
立体化学
生物
体外
生物化学
遗传学
作者
Jin Cai,Xiu-Lan Cao,Bin Wang,Liu Jing,Min-Jing Chen,Yun-Zhan Luo,Xuelong Zhang,Peng Li,Cai‐Juan Zheng
标识
DOI:10.1080/14786419.2022.2164279
摘要
A series of secondary metabolites have been isolated from the genus of Bacillus velezensis, most of which show antibacterial and insecticidal activities. In order to find more bioactive secondary metabolites from B. velezensis, one new natural component aminoindole dimer baciindole A (1), together with seven known compounds (2-8) were isolated from the tomato-derived bacterium Bacillus velezensis Hnu24. The structure of compound 1 was elucidated by its HR-ESI-MS spectral data and 1 D/2D NMR spectroscopic analysis. Compound 3 showed antibacterial activity against Staphylococcus aureus, S. epidermidis and Ralstonia solanacearum with the MIC values of 3.125, 12.5 and 50 μg/mL, respectively. Compound 4 showed antibacterial activity against S. aureus with the MIC value of 12.5 μg/mL. Compound 3 showed cytotoxic activity for human colon cancer HTC116 cancer cells with the IC50 value of 8.42 ± 0.48 μM. Five compounds (1-4 and 8) were obtained from the strain of B. velezensis for the first time. These results indicated that 3 will be useful in developing antimicrobial and treatment of colon cancer agents.
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