Effect of low-level laser therapy plus exercise therapy on pain, range of motion, muscle strength, and function in knee osteoarthritis – a systematic review and meta-analysis

AbstractBackground Knee osteoarthritis (KOA) is commonly associated with multiple musculoskeletal impairments.Objective The purpose of this review was (1) to investigate the effectiveness of LLLT plus ET on pain, ROM, muscle strength, and function in KOA immediately after therapy and (2) whether the effectiveness of LLLT plus ET could be sustained at follow-up (4 - 32 weeks).Methods Six databases were systematically searched upto December 2021 to find relevant articles. Included studies were RCTs written in English, which compared LLLT plus ET with placebo LLLT plus ET in KOA. Three independent reviewers extracted data and assessed the quality of included studies. Standard mean difference (SMD) was used in meta-analysis using random effect model.Result Of the 6307 articles, 14 RCTs (820 patients) met the inclusion criteria. The results demonstrated that there was a significant difference in pain immediately after therapy (SMD: −0.58, p = 0.001) and at follow-up (SMD: −1.35, p = 0.05) in LLLT plus ET group. There were no significant differences in knee ROM, muscle strength, and knee function outcomes immediately and at follow-up.Conclusion Our findings indicate that LLLT plus ET could be considered to alleviate pain in the KOA. LLLT reduces pain at 4–8J with a wavelength of 640–905nm per point applied for 10–16 sessions at a frequency of 2 sessions/week. An exercise therapy program at prescribed dosage involving major muscle groups might help. However, LLLT plus ET is no more effective than placebo LLLT plus ET in improving ROM, muscle strength, and function in KOA.Keywords: Low-level laser therapyexercisephotobiomodulationknee osteoarthritispaindisability Correction StatementThis article has been corrected with minor changes. These changes do not impact the academic content of the article.AcknowledgmentThe authors thank the University for providing the necessary support for carrying out the research.Disclosure statementNo potential conflict of interest was reported by the author(s).Data availability statementAll relevant data are within the paper and its Supporting Information files.