增食欲素
食欲素-A
信号转导
能量稳态
神经科学
食欲素受体
G蛋白偶联受体
神经肽
外侧下丘脑
受体
生物
细胞生物学
内科学
化学
下丘脑
医学
作者
Oishi Chatterjee,Lathika Gopalakrishnan,Deepshika Pullimamidi,Chinmayi Raj,Soujanya D. Yelamanchi,Bhavya Somaplara Gangadharappa,Bipin G. Nair,Anita Mahadevan,Rajesh Raju,T. S. Keshava Prasad
标识
DOI:10.1007/s12079-022-00700-3
摘要
Orexins are excitatory neuropeptides, which are predominantly associated with feeding behavior, sleep-wake cycle and energy homeostasis. The orexinergic system comprises of HCRTR1 and HCRTR2, G-protein-coupled receptors of rhodopsin family and the endogenous ligands processed from HCRT pro-hormone, Orexin A and Orexin B. These neuropeptides are biosynthesized by the orexin neurons present in the lateral hypothalamus area, with dense projections to other brain regions. The orexin-receptor signaling is implicated in various metabolic as well as neurological disorders, making it a promising target for pharmacological interventions. However, there is limited information available on the collective representation of the signal transduction pathways pertaining to the orexin-orexin receptor signaling system. Here, we depict a compendium of the Orexin A/B stimulated reactions in the form of a basic signaling pathway map. This map catalogs the reactions into five categories: molecular association, activation/inhibition, catalysis, transport, and gene regulation. A total of 318 downstream molecules were annotated adhering to the guidelines of NetPath curation. This pathway map can be utilized for further assessment of signaling events associated with orexin-mediated physiological functions and is freely available on WikiPathways, an open-source pathway database ( https://www.wikipathways.org/index.php/Pathway:WP5094 ).
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