医学
特发性肺纤维化
内科学
心脏病学
心力衰竭
危险系数
比例危险模型
肺功能测试
肺
置信区间
标识
DOI:10.1183/13993003.congress-2022.147
摘要
Background: Idiopathic pulmonary fibrosis (IPF) is a rare lung disease with high mortality. Cardiopulmonary exercise test (CPET) has been demonstrated to predict the mortality risk in patients with dilated cardiomyopathy and congestive heart failure. However, CPET is not a routine diagnostic and monitoring tool in patients with newly diagnosed IPF. In addition, research regarding the prognostic value of CPET in IPF remains limited. Methods: We prospectively enrolled patients with new diagnosed with IPF from the registry cohort. The patients were then followed up for 12 months to trace the incidence of mortality. The participants completed SGRQ), SF-36 and mMRC dyspnea questionnaires on the index day. Serial examinations included lung function test, 6MWT, and CPET were arranged and completed. Cox proportional hazard regression models was used to determine independent predictors of one-year mortality. Results: A total of 34 patients newly diagnosed as IPF were enrolled from December 2018 to December 2019. The 1-year mortality rate was 17.6%. Cox analysis showed that higher minute ventilation to carbon dioxide output (VE/VCO2) slope (Haz-ard ratio, HR: 1.14, 95% Confident interval, CI: 1.01-1.28), end-tidal partial pressure of carbon dioxide (PETCO2) (HR: 0.11, 95% CI: 0.01- 0.85) and higher dead space (Vd/Vt) (HR: 1.13, 95% CI: 1.01-1.27) were associated with 1-year mortality. The corresponding cut-off values of VE/VCO2 slope, and PETCO2 were 35.1 and 3.6 kPa, respectively. Conclusion: CPET may provide prognostic value of 1-year mortality in patients with newly diagnosed IPF.
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