生物
糖尿病性视网膜病变
癌症研究
小RNA
糖尿病
细胞生物学
内分泌学
遗传学
基因
作者
Shuai He,Dongwei Lai,Chenggong Ma,Chunren Meng,Chunyang Cai,Qian Chen,Chufeng Gu,Qinghua Qiu
出处
期刊:Epigenomics
[Future Medicine]
日期:2024-04-01
卷期号:16 (7): 427-444
被引量:1
标识
DOI:10.2217/epi-2023-0359
摘要
Objective: To elucidate the role of the competitive endogenous RNA (ceRNA) network in immune infiltration of diabetic retinopathy (DR). Methods: We obtained differentially expressed (DE) circRNAs, miRNAs and mRNAs from the Gene Expression Omnibus database. Then, we identified immune infiltration by CIBERSORT and single-sample gene set enrichment analysis and discovered co-expression genes by weighted gene co-expression network analysis. Furthermore, STAT1-mediated Th1 differentiation was determined in DR cell models, DR patients and DR mouse models. Results: hsa_circ_0087100/hsa-miR-6743-5p/STAT1 was involved in immune infiltration of Th1 cells. Aberrant expression of the ceRNA network and STAT1-mediated Th1 differentiation was thus verified in vitro and in vivo. Conclusion: hsa_circ_0087100/hsa-miR-6743-5p/STAT1 may affect Th1 cell differentiation in DR.
科研通智能强力驱动
Strongly Powered by AbleSci AI