医学
内皮素受体
肾脏疾病
肾
疾病
内科学
内皮素1
内分泌学
心脏病学
受体
作者
Ernesto L. Schiffrin,David M. Pollock
出处
期刊:Hypertension
[Ovid Technologies (Wolters Kluwer)]
日期:2024-04-01
卷期号:81 (4): 691-701
被引量:1
标识
DOI:10.1161/hypertensionaha.123.21716
摘要
ET (endothelin) is a powerful vasoconstrictor 21-amino acid peptide present in many tissues, which exerts many physiological functions across the body and participates as a mediator in many pathological conditions. ETs exert their effects through ET A and ET B receptors, which can be blocked by selective receptor antagonists. ETs were shown to play important roles among others, in systemic hypertension, particularly when resistant or difficult to control, and in pulmonary hypertension, atherosclerosis, cardiac hypertrophy, subarachnoid hemorrhage, chronic kidney disease, diabetic cardiovascular disease, scleroderma, some cancers, etc. To date, ET antagonists are only approved for the treatment of primary pulmonary hypertension and recently for IgA nephropathy and used in the treatment of digital ulcers in scleroderma. However, they may soon be approved for the treatment of patients with resistant hypertension and different types of nephropathy. Here, the role of ETs is reviewed with a special emphasis on participation in and treatment of hypertension and chronic kidney disease.
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