Recent Advances in Synthetic Routes for Biologically Active Tetrahydroquinoxalines and Derivatives: A Comprehensive Review

Abstract: Tetrahydroquinoxalines are found in many biologically and pharmacologically active small molecules. In the past two decades, significant progress has been made in the development of novel synthetic routes for the preparation of biologically active tetrahydroquinoxalines and their derivatives. This synthetic review aims to provide a comprehensive overview of the advancements in the field of various synthetic strategies and methodologies employed for the synthesis of tetrahydroquinoxaline scaffolds during this period. The review emphasizes the diverse synthetic approaches employed, including cycloaddition reactions, condensation reactions, intramolecular cyclization reactions, ring expansion reactions, hydrogenation reactions, and other miscellaneous methods.