疾病
认知
认知功能衰退
医学
阿尔茨海默病
人口
睡眠剥夺对认知功能的影响
生物标志物
痴呆
神经科学
心理学
生物
病理
生物化学
环境卫生
作者
G. García-Escobar,R.M. Manero,Aida Fernández‐Lebrero,Ángel Ois,Irene Navalpotro‐Gómez,Víctor Puente‐Periz,José Contador-Muñana,Isabel Estragués-Gázquez,Albert Puig‐Pijoan,Joan Jiménez-Baladó
出处
期刊:Biomolecules
[MDPI AG]
日期:2024-01-11
卷期号:14 (1): 93-93
被引量:3
摘要
Recent advances in blood-based biomarkers of Alzheimer’s Disease (AD) show great promise for clinical applications, offering a less invasive alternative to current cerebrospinal fluid (CSF) measures. However, the relationships between these biomarkers and specific cognitive functions, as well as their utility in predicting longitudinal cognitive decline, are not yet fully understood. This descriptive review surveys the literature from 2018 to 2023, focusing on the associations of amyloid-β (Aβ), Total Tau (t-Tau), Phosphorylated Tau (p-Tau), Neurofilament Light (NfL), and Glial Fibrillary Acidic Protein (GFAP) with cognitive measures. The reviewed studies are heterogeneous, varying in design and population (cognitively unimpaired, cognitively impaired, or mixed populations), and show results that are sometimes conflicting. Generally, cognition positively correlates with Aβ levels, especially when evaluated through the Aβ42/Aβ40 ratio. In contrast, t-Tau, p-Tau, Nfl, and GFAP levels typically show a negative correlation with cognitive performance. While p-Tau measures generally exhibit stronger associations with cognitive functions compared to other biomarkers, no single blood marker has emerged as being predominantly linked to a specific cognitive domain. These findings contribute to our understanding of the complex relationship between blood biomarkers and cognitive performance and underscore their potential utility in clinical assessments of cognition.
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