Changes in Adiposity and Cognitive Function in Older Adults: The REGARDS Study

认知功能衰退 体质指数 认知 老年学 口语流利性测试 医学 人口学 痴呆 腰围 逻辑回归 重量变化 心理学 肥胖 减肥 神经心理学 内科学 精神科 疾病 社会学
作者
Wenfei Zhu,Yanbing Li,Chenxi Zhao,Virginia J. Howard,Virginia G. Wadley,Suzanne E. Judd,Natalie Colabianchi,Leslie A. McClure,Steven P. Hooker,Yuliang Sun
出处
期刊:The Journals of Gerontology: Series B [Oxford University Press]
卷期号:79 (3) 被引量:1
标识
DOI:10.1093/geronb/gbad184
摘要

Abstract Objectives Adiposity may have a role in the risk of dementia. Fewer studies have focused on the relationship between change in adiposity and cognitive decline. Our study aimed to explore the association between the change in adiposity and cognitive function in Black and White older adults. Methods The participants were 12,204 older adults without cognitive impairment (62.8 ± 8.0 years) in the United States. The percent body mass index change (%BMI change) and percent waist circumference change (%WC change) were measured at 2 in-home visits (first: 2003–2007, second: 2013–2016). Cognitive status was assessed by the Six-Item Screener annually. Memory and executive function were measured by word list learning, MOCA recall and orientation, and letter and animal fluency every 2 years. Logistic regression or linear regression models were used to estimate the relationship between percent change in adiposity and cognitive function. Results After 12.7 ± 1.7 years, a greater decrease in %BMI change or %WC change was significantly associated with a higher risk of cognitive impairment. Compared to older adults with −5% ≤ change ≤ 5% from baseline, a significantly higher risk of cognitive impairment and greater loss in memory and executive function were found among those who experienced more than a 10% decline in %BMI change or %WC change. Older adults who experienced a 5%–10% decrease in %BMI change had a higher risk of cognitive impairment and greater loss of memory compared to those with −5% ≤ change ≤ 5%. Discussion A greater decrease in %BMI (>5%) and %WC (>10%) change was associated with greater cognitive loss observed over time.
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