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Cortical myelin and thickness mapping provide insights into whole-brain tumor burden in diffuse midline glioma

胶质瘤 中央后回 医学 髓鞘 病理 中央前回 神经科学 磁共振成像 生物 放射科 内科学 中枢神经系统 癌症研究
作者
Simin Zhang,Xibiao Yang,Qiaoyue Tan,Huaiqiang Sun,Di Chen,Yinying Chen,Hongjing Zhang,Yuan Yang,Qiyong Gong,Qiang Yue
出处
期刊:Cerebral Cortex [Oxford University Press]
卷期号:34 (1) 被引量:1
标识
DOI:10.1093/cercor/bhad491
摘要

Abstract Systemic infiltration is a hallmark of diffuse midline glioma pathogenesis, which can trigger distant disturbances in cortical structure. However, the existence and effects of these changes have been underexamined. This study aimed to investigate whole-brain cortical myelin and thickness alternations induced by diffuse midline glioma. High-resolution T1- and T2-weighted images were acquired from 90 patients with diffuse midline glioma with H3 K27-altered and 64 patients with wild-type and 86 healthy controls. Cortical thickness and myelin content was calculated using Human Connectome Project pipeline. Significant differences in cortical thickness and myelin content were detected among groups. Short-term survival prediction model was constructed using automated machine learning. Compared with healthy controls, diffuse midline glioma with H3 K27-altered patients showed significantly reduced cortical myelin in bilateral precentral gyrus, postcentral gyrus, insular, parahippocampal gyrus, fusiform gyrus, and cingulate gyrus, whereas diffuse midline glioma with H3 K27 wild-type patients exhibited well-preserved myelin content. Furtherly, when comparing diffuse midline glioma with H3 K27-altered and diffuse midline glioma with H3 K27 wild-type, the decreased cortical thickness in parietal and occipital regions along with demyelination in medial orbitofrontal cortex was observed in diffuse midline glioma with H3 K27-altered. Notably, a combination of cortical features and tumor radiomics allowed short-term survival prediction with accuracy 0.80 and AUC 0.84. These findings may aid clinicians in tailoring therapeutic approaches based on cortical characteristics, potentially enhancing the efficacy of current and future treatment modalities.
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