亲爱的研友该休息了!由于当前在线用户较少,发布求助请尽量完整地填写文献信息,科研通机器人24小时在线,伴您度过漫漫科研夜!身体可是革命的本钱,早点休息,好梦!

Cortical myelin and thickness mapping provide insights into whole-brain tumor burden in diffuse midline glioma

胶质瘤 中央后回 医学 髓鞘 病理 中央前回 神经科学 磁共振成像 生物 放射科 内科学 中枢神经系统 癌症研究
作者
Simin Zhang,Xibiao Yang,Qiaoyue Tan,Huaiqiang Sun,Di Chen,Yinying Chen,Hongjing Zhang,Yuan Yang,Qiyong Gong,Qiang Yue
出处
期刊:Cerebral Cortex [Oxford University Press]
卷期号:34 (1) 被引量:1
标识
DOI:10.1093/cercor/bhad491
摘要

Abstract Systemic infiltration is a hallmark of diffuse midline glioma pathogenesis, which can trigger distant disturbances in cortical structure. However, the existence and effects of these changes have been underexamined. This study aimed to investigate whole-brain cortical myelin and thickness alternations induced by diffuse midline glioma. High-resolution T1- and T2-weighted images were acquired from 90 patients with diffuse midline glioma with H3 K27-altered and 64 patients with wild-type and 86 healthy controls. Cortical thickness and myelin content was calculated using Human Connectome Project pipeline. Significant differences in cortical thickness and myelin content were detected among groups. Short-term survival prediction model was constructed using automated machine learning. Compared with healthy controls, diffuse midline glioma with H3 K27-altered patients showed significantly reduced cortical myelin in bilateral precentral gyrus, postcentral gyrus, insular, parahippocampal gyrus, fusiform gyrus, and cingulate gyrus, whereas diffuse midline glioma with H3 K27 wild-type patients exhibited well-preserved myelin content. Furtherly, when comparing diffuse midline glioma with H3 K27-altered and diffuse midline glioma with H3 K27 wild-type, the decreased cortical thickness in parietal and occipital regions along with demyelination in medial orbitofrontal cortex was observed in diffuse midline glioma with H3 K27-altered. Notably, a combination of cortical features and tumor radiomics allowed short-term survival prediction with accuracy 0.80 and AUC 0.84. These findings may aid clinicians in tailoring therapeutic approaches based on cortical characteristics, potentially enhancing the efficacy of current and future treatment modalities.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
5秒前
佟语雪完成签到,获得积分10
5秒前
轻松的惜芹应助喂喂采纳,获得10
9秒前
淳于如雪发布了新的文献求助10
12秒前
LLL完成签到 ,获得积分10
16秒前
yar应助淳于如雪采纳,获得10
17秒前
Koking关注了科研通微信公众号
22秒前
23秒前
淳于如雪完成签到,获得积分20
25秒前
lv发布了新的文献求助10
26秒前
我是老大应助吴嘉俊采纳,获得10
29秒前
30秒前
在水一方应助阿九采纳,获得10
35秒前
35秒前
ZT完成签到,获得积分10
39秒前
搜集达人应助zhouleiwang采纳,获得10
40秒前
吴嘉俊发布了新的文献求助10
41秒前
仙人掌王朝完成签到,获得积分10
43秒前
46秒前
Hello应助zhouleiwang采纳,获得10
46秒前
阿九完成签到,获得积分10
49秒前
lllxxx完成签到 ,获得积分10
50秒前
lv发布了新的文献求助10
51秒前
冉亦完成签到,获得积分10
55秒前
WGS完成签到,获得积分10
56秒前
科研通AI2S应助科研通管家采纳,获得10
57秒前
华仔应助科研通管家采纳,获得20
57秒前
吉吉吉完成签到 ,获得积分10
59秒前
1分钟前
阿九发布了新的文献求助10
1分钟前
大胆的小懒猪完成签到 ,获得积分10
1分钟前
111完成签到 ,获得积分10
1分钟前
1分钟前
yx_cheng应助001az采纳,获得30
1分钟前
1分钟前
miles完成签到,获得积分10
1分钟前
简单山水发布了新的文献求助10
1分钟前
Yina完成签到 ,获得积分10
1分钟前
友好胜完成签到 ,获得积分10
1分钟前
田様应助滴滴哒采纳,获得10
1分钟前
高分求助中
The Mother of All Tableaux: Order, Equivalence, and Geometry in the Large-scale Structure of Optimality Theory 3000
A new approach to the extrapolation of accelerated life test data 1000
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
Indomethacinのヒトにおける経皮吸収 400
Phylogenetic study of the order Polydesmida (Myriapoda: Diplopoda) 370
基于可调谐半导体激光吸收光谱技术泄漏气体检测系统的研究 350
Robot-supported joining of reinforcement textiles with one-sided sewing heads 320
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3990012
求助须知:如何正确求助?哪些是违规求助? 3532049
关于积分的说明 11256153
捐赠科研通 3270925
什么是DOI,文献DOI怎么找? 1805123
邀请新用户注册赠送积分活动 882270
科研通“疑难数据库(出版商)”最低求助积分说明 809216