间充质干细胞
间皮细胞
肿瘤微环境
癌症研究
生物
化学
细胞生物学
病理
医学
肿瘤细胞
作者
Atsuko Yonemura,Takashi Semba,Jun Zhang,Yibo Fan,Noriko Yasuda‐Yoshihara,Huaitao Wang,Tomoyuki Uchihara,Tadahito Yasuda,Akiho Nishimura,Lingfeng Fu,Xichen Hu,Feng Wei,Fumimasa Kitamura,Takahiko Akiyama,Kohei Yamashita,Kojiro Eto,Shiro Iwagami,Masaaki Iwatsuki,Yuji Miyamoto,Keisuke Matsusaki
出处
期刊:Cell Reports
[Cell Press]
日期:2024-01-01
卷期号:43 (1): 113613-113613
被引量:10
标识
DOI:10.1016/j.celrep.2023.113613
摘要
Malignant ascites accompanied by peritoneal dissemination contain various factors and cell populations as well as cancer cells; however, how the tumor microenvironment is shaped in ascites remains unclear. Single-cell proteomic profiling and a comprehensive proteomic analysis are conducted to comprehensively characterize malignant ascites. Here, we find defects in immune effectors along with immunosuppressive cell accumulation in ascites of patients with gastric cancer (GC) and identify five distinct subpopulations of CD45(-)/EpCAM(-) cells. Mesothelial cells with mesenchymal features in CD45(-)/EpCAM(-) cells are the predominant source of chemokines involved in immunosuppressive myeloid cell (IMC) recruitment. Moreover, mesothelial-mesenchymal transition (MMT)-induced mesothelial cells strongly express extracellular matrix (ECM)-related genes, including tenascin-C (TNC), enhancing metastatic colonization. These findings highlight the definite roles of the mesenchymal cell population in the development of a protumorigenic microenvironment to promote peritoneal dissemination.
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