微晶纤维素
结晶度
易碎性
纤维素
粒径
化学工程
材料科学
化学
核化学
有机化学
复合材料
聚合物
乙基纤维素
工程类
作者
Hao Xiao,Zhongjian Tian,Yingchao Wang,Zhaoyong Xie,Xingxiang Ji
标识
DOI:10.1016/j.ijbiomac.2024.130532
摘要
As a bio-based material, microcrystalline cellulose (MCC) has been applied in many fields including pharmaceuticals, foods, and cosmetics in recent years. However, traditional preparation methods of MCC are facing many challenges due to economic and eco-environmental issues. In this study, softwood dissolved pulp was sieved to long fiber (LF) and short fiber (SF), and subsequently to prepare LF-MCC and SF-MCC by hydrochloric acid hydrolysis at different acid dosages (3–7 wt%), reaction times (30–90 min), and temperatures (75–95 °C). The as-obtained MCC products were compared in terms of morphology, size, crystallinity, and chemical structure. The results indicated that the crystallinity and yield of LF-MCC were high, with maximum values of 78.41 % and 98.68 %, respectively. The particle size distribution of SF-MCC was more uniform in the range of 20–80 μm, with a maximum of 59.44 % at 20–80 μm occupancy proportion. Moreover, SF-MCC had a typical rod-like shape and larger surface area as well as better thermal behavior than LF-MCC. When LF-MCC and SF-MCC were used as fillers in the production of ibuprofen tablets, the tablets added with LF-MCC exhibited higher hardness, friability, dissolution rate, and shorter disintegration time. Therefore, this work is very beneficial for the preparation and application of MCC.
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