Comparative efficacy of multiple non‐pharmacological interventions for behavioural and psychological symptoms of dementia: A network meta‐analysis of randomised controlled trials

痴呆 冷漠 随机对照试验 医学 荟萃分析 生活质量(医疗保健) 心理干预 置信区间 物理疗法 严格标准化平均差 内科学 精神科 疾病 护理部
作者
Zihan Yin,Yaqin Li,Qiong-Nan Bao,Xinyue Zhang,Manze Xia,Wan-Qi Zhong,Kexin Wu,Jin Yao,Zhenghong Chen,Mingsheng Sun,Ling Zhao,Fanrong Liang
出处
期刊:International Journal of Mental Health Nursing [Wiley]
卷期号:33 (3): 487-504 被引量:14
标识
DOI:10.1111/inm.13254
摘要

Non-pharmacological interventions can improve the behavioural and psychological symptoms of dementia (BPSD). However, the optimal non-pharmacological treatments remain controversial. This study aimed to compare the efficacy of multiple non-pharmacological methods and identify the optimal therapy for BPSD. Potential randomised controlled trials (RCTs) were searched and selected from 15 databases and sources from the inception of the databases until 1 October 2022. Two independent authors implemented study screening, data extraction, and methodological quality assessment. Primary outcome was reduction of Neuropsychiatric Inventory (NPI). The secondary outcome were changes of Cornell Scale for Depression in Dementia (CSDD), the Cohen-Mansfield Agitation Inventory (CMAI), the Quality of Life in Alzheimer's Disease (QoL-AD), the Abilities of Daily Living scale, and the Apathy Evaluation Scale. Meta-analyses were performed using STATA v15.0 and ADDIS v1.16.8. The GRADE approaches were utilised to evaluate evidence quality. The present study included 43 RCTs with 4978 participants. The global methodological quality of the RCTs was moderate. Regarding NPI reduction, with moderate-certainty evidence, exercise plus treatment as usual (TAU) outperformed TAU (mean difference [MD]: -7.13; 95% confidence interval [CI]: -13.22, -0.76) and ranked as the optimal treatment. For reduction in CSDD, with low- to moderate-certainty evidence, massage plus TAU (MD: -15.26; 95% CI: -20.13, -10.52) and music plus TAU (MD: -2.40; 95% CI: -4.62, -0.12) were associated with greater reduction compared with TAU. For reduction in CMAI, with moderate-certainty evidence, aromatherapy plus massage (MD: -15.84; 95% CI: -29.76, -2.42) and massage plus music (MD: -13.12; 95% CI: -25.43, -0.76) were significantly more effective than TAU. For improvement in QoL-AD, with critically low- to low-certainty evidence, there were no statistical differences between any of non-pharmacological treatments and TAU. Due to the limited number of included studies, network meta-analysis was not performed for other outcomes. In conclusion, non-pharmacological treatments are effective for overall symptoms, depression, and agitation. Exercise plus treatment as usual may be an optimal non-pharmacological intervention for improving the overall BPSD. This may help to guide patients, doctors, and policymakers.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
journey完成签到 ,获得积分10
1秒前
4秒前
乖猫要努力应助潇湘雪月采纳,获得10
7秒前
一行发布了新的文献求助10
7秒前
storm完成签到,获得积分10
10秒前
HOPE完成签到,获得积分20
11秒前
Singularity应助Xiaoyang采纳,获得10
13秒前
ding应助快乐一江采纳,获得10
13秒前
14秒前
步一完成签到,获得积分10
15秒前
18秒前
情怀应助科研通管家采纳,获得10
18秒前
SYLH应助科研通管家采纳,获得10
18秒前
SYLH应助科研通管家采纳,获得10
19秒前
烟花应助科研通管家采纳,获得10
19秒前
在水一方应助科研通管家采纳,获得10
19秒前
dongjy应助科研通管家采纳,获得150
19秒前
Owen应助科研通管家采纳,获得10
19秒前
fd163c应助科研通管家采纳,获得10
19秒前
大模型应助科研通管家采纳,获得10
19秒前
SciGPT应助科研通管家采纳,获得10
19秒前
Owen应助科研通管家采纳,获得10
19秒前
19秒前
愉快的牛氓完成签到 ,获得积分10
21秒前
恋雅颖月应助潇湘雪月采纳,获得10
23秒前
25秒前
传奇3应助热情青亦采纳,获得10
26秒前
CodeCraft应助夕沫采纳,获得10
27秒前
江江发布了新的文献求助10
30秒前
斯文败类应助sirhai采纳,获得10
32秒前
只谈风月完成签到,获得积分10
33秒前
顾矜应助哈哈呵采纳,获得10
34秒前
科研助手6应助风中的南风采纳,获得10
34秒前
小马甲应助呆瓜采纳,获得10
34秒前
35秒前
热情青亦完成签到,获得积分10
35秒前
35秒前
36秒前
36秒前
lw完成签到,获得积分10
37秒前
高分求助中
A new approach to the extrapolation of accelerated life test data 1000
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
‘Unruly’ Children: Historical Fieldnotes and Learning Morality in a Taiwan Village (New Departures in Anthropology) 400
Indomethacinのヒトにおける経皮吸収 400
Phylogenetic study of the order Polydesmida (Myriapoda: Diplopoda) 370
基于可调谐半导体激光吸收光谱技术泄漏气体检测系统的研究 350
Robot-supported joining of reinforcement textiles with one-sided sewing heads 320
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3989390
求助须知:如何正确求助?哪些是违规求助? 3531487
关于积分的说明 11254109
捐赠科研通 3270153
什么是DOI,文献DOI怎么找? 1804887
邀请新用户注册赠送积分活动 882087
科研通“疑难数据库(出版商)”最低求助积分说明 809174