医学
孟德尔随机化
人口
免疫学
免疫系统
趋化因子
冠状动脉疾病
生物信息学
内科学
生物
基因
遗传学
环境卫生
基因型
遗传变异
作者
Savvina Prapiadou,Luka Živković,Barbara Thorand,Marc J. George,Sander W. van der Laan,Rainer Malik,Christian Herder,Wolfgang Köenig,Thor Ueland,Ola Kleveland,Pål Aukrust,Lars Gullestad,Jürgen Bernhagen,Gerard Pasterkamp,Annette Peters,Aroon D. Hingorani,Jonathan Rosand,Martin Dichgans,Christopher D. Anderson,Marios K. Georgakis
出处
期刊：Circulation
[Lippincott Williams & Wilkins]
日期：2023-12-28
卷期号：149 (9): 669-683
被引量：15
标识
DOI：10.1161/circulationaha.123.064974
摘要
Genetic and experimental studies support a causal involvement of IL-6 (interleukin-6) signaling in atheroprogression. Although trials targeting IL-6 signaling are underway, any benefits must be balanced against an impaired host immune response. Dissecting the mechanisms that mediate the effects of IL-6 signaling on atherosclerosis could offer insights about novel drug targets with more specific effects.
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