已入深夜,您辛苦了!由于当前在线用户较少,发布求助请尽量完整地填写文献信息,科研通机器人24小时在线,伴您度过漫漫科研夜!祝你早点完成任务,早点休息,好梦!

Efficacy of hemoporfin-mediated photodynamic therapy in treating Sturge–Weber syndrome associated port-wine stains: A retrospective study

医学 光动力疗法 Sturge-Weber综合征 不利影响 皮肤病科 波尔图葡萄酒 葡萄酒色斑 磁共振成像 内科学 眼科 外科 放射科 激光器 有机化学 化学 物理 光学
作者
Yuanbo Huang,Bin Chen,Jun Yang,Mingye Bi,Linbo Bi,Weixin Fan
出处
期刊:Indian Journal of Dermatology, Venereology and Leprology [Medknow]
卷期号:90: 202-209 被引量:3
标识
DOI:10.25259/ijdvl_1075_2022
摘要

Background Sturge-Weber syndrome (SWS) is a rare condition associated with a GNAQ gene mutation, which affects neural crest cells. A pulsed dye laser (PDL) is a first-line therapy for SWS, but its outcomes are worse than those in patients with port-wine stains (PWS). Photodynamic therapy (PDT) is a promising therapeutic option for PWS. However, its use for PWS associated with SWS has rarely been studied. Aims To investigate the therapeutic and adverse effects of photodynamic therapy in treating SWS-associated PWS. Methods Patients with SWS and matched patients with large size facial PWS were included in this study. Both colorimetric assessment and visual evaluation were conducted to evaluate patients' responses to treatment. Results Colorimetric assessment (blanching rate) and visual evaluation (scores of colour improvement) showed that after two PDT treatments, the SWS and PWS groups had similar treatment responses (21.2% vs. 29.8%; 3.39 vs. 3.65; P = 0.18, P = 0.37). However, there was a significant difference in efficacy between patients with SWS with and without a treatment history (12.4 and 34.9%, respectively; P = 0.02), as well as between patients with lesions located on the central and lateral faces (18.5 and 36.8%, respectively; P = 0.01). Both the SWS and PWS groups experienced minor adverse effects, and the frequency of these effects was not significantly different between the two groups. Limitation The study was limited by a small sample size and the possibility of later onset of glaucoma. In addition, false-negative magnetic resonance imaging screening results for SWS could not be ruled out due to the young age of some participants. Conclusion Photodynamic therapy is a safe and effective therapeutic option for SWS-associated PWS. Patients without a treatment history, and lesions on the lateral face, responded well, demonstrating good efficacy.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
柚子完成签到 ,获得积分10
刚刚
刚刚
luwenxuan发布了新的文献求助10
3秒前
5秒前
Hello应助哈哈哈哈采纳,获得10
8秒前
光亮静槐完成签到 ,获得积分10
9秒前
10秒前
朴实的热狗关注了科研通微信公众号
11秒前
14秒前
小凉完成签到 ,获得积分10
15秒前
16秒前
17秒前
Kirito完成签到,获得积分0
17秒前
zero1122发布了新的文献求助10
18秒前
哈哈哈哈完成签到,获得积分10
18秒前
wangch198201完成签到 ,获得积分10
19秒前
lyy66964193完成签到,获得积分10
20秒前
哈哈哈哈发布了新的文献求助10
22秒前
清爽源智发布了新的文献求助10
22秒前
nature发布了新的文献求助10
23秒前
善学以致用应助luwenxuan采纳,获得10
23秒前
似水流年完成签到 ,获得积分10
25秒前
Doki发布了新的文献求助10
26秒前
lutiantian发布了新的文献求助10
28秒前
酷波er应助瑾钰满糖采纳,获得10
29秒前
30秒前
卡皮巴拉完成签到,获得积分10
30秒前
清爽源智完成签到,获得积分10
33秒前
35秒前
漂亮采波完成签到,获得积分10
36秒前
YamDaamCaa应助科研顺利啦采纳,获得50
37秒前
敏感的南露完成签到,获得积分10
39秒前
Nefelibata完成签到,获得积分10
40秒前
bystanding完成签到,获得积分10
40秒前
慕青应助zty123采纳,获得10
42秒前
彪壮的银耳汤完成签到 ,获得积分10
44秒前
轩辕山槐完成签到,获得积分10
50秒前
51秒前
zty123完成签到,获得积分10
53秒前
大树完成签到 ,获得积分10
55秒前
高分求助中
A new approach to the extrapolation of accelerated life test data 1000
Picture Books with Same-sex Parented Families: Unintentional Censorship 700
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
Nucleophilic substitution in azasydnone-modified dinitroanisoles 500
不知道标题是什么 500
Indomethacinのヒトにおける経皮吸収 400
Phylogenetic study of the order Polydesmida (Myriapoda: Diplopoda) 370
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3976600
求助须知:如何正确求助?哪些是违规求助? 3520674
关于积分的说明 11204422
捐赠科研通 3257298
什么是DOI,文献DOI怎么找? 1798683
邀请新用户注册赠送积分活动 877842
科研通“疑难数据库(出版商)”最低求助积分说明 806595