Serum Ionized Calcium as a Prognostic Biomarker in Type B Aortic Dissection After Endovascular Treatment

医学 倾向得分匹配 内科学 主动脉夹层 心脏病学 人口 不利影响 生物标志物 外科 主动脉 生物化学 环境卫生 化学
作者
Hongqiao Zhu,Bei Hu,Heng Zhang,Haiyan Li,Jian Zhou,Zaiping Jing
出处
期刊:Journal of Endovascular Therapy [SAGE Publishing]
卷期号:: 152660282311683-152660282311683
标识
DOI:10.1177/15266028231168348
摘要

Objective: Lower serum ionized calcium (iCa 2+ ) was reported to be associated with a higher risk of adverse events in patients with cardiovascular diseases. This study aimed to investigate the associations between preoperative serum iCa 2+ and outcomes of type B aortic dissection (TBAD) patients receiving thoracic endovascular aortic repair (TEVAR). Methods: Between January 2016 and December 2019, 491 TBAD patients received TEVAR in a single center. Patients with acute or subacute TBAD were included. Serum iCa 2+ (pH 7.4) was obtained from the arterial blood gas analysis before TEVAR. The study population was grouped into the hi-Ca group (1.11 mmol/L ≤ iCa 2+ < 1.35 mmol/L) and lo-Ca group (iCa 2+ < 1.11 mmol/L). The primary outcomes were all-cause mortality. The secondary outcomes were any major adverse clinical events (MACEs), which included all-cause mortality and aortic-related severe complications. To eliminate bias, 1:1 propensity score matching (PSM) was conducted. Results: Overall, 396 TBAD patients were included in this study. In the total population, there were 119 (30.1%) patients in the lo-Ca group. After PSM, 77 matched pairs were obtained for further analysis. In the matched population, the 30-day mortality and 30-day MACEs between the two groups presented significant differences (p=0.023 and 0.029, respectively). At 5 years, cumulative incidences of mortality (log-rank p<0.001) and MACEs (log-rank p=0.016) were significantly higher in the lo-Ca group than that of the hi-Ca group. Multivariate cox regression analysis indicated that lower preoperative iCa 2+ (hazard ratio for per 0.1 mmol/L decrease, 2.191; 95% confidence interval, 1.487–3.228, p<0.001) was an independent risk factor for 5-year mortality after PSM. Conclusions: Lower preoperative serum iCa 2+ might have an association with 5-year mortality in TBAD patients after TEVAR. Serum iCa 2+ monitoring in this population may facilitate the identification of critical conditions. Clinical Impact Our present study found that the cutoff value of preoperative serum iCa 2+ 1.11 mmol/L, which is slightly lower than the lower limit of the normal range of 1.15-1.35 mmol/L, worked relatively well for discerning the high-risk and low-risk TBAD patients at 5 years. Serum iCa 2+ monitoring in TBAD patients receiving TEVAR may facilitate the identification of critical conditions.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
去有风的地方完成签到 ,获得积分10
2秒前
上下完成签到 ,获得积分10
4秒前
王娟秀完成签到 ,获得积分10
5秒前
YL完成签到,获得积分10
7秒前
NexusExplorer应助小王采纳,获得10
8秒前
8秒前
sl完成签到,获得积分10
8秒前
CC完成签到,获得积分10
9秒前
自信松思完成签到 ,获得积分10
10秒前
荣枫完成签到,获得积分10
10秒前
10秒前
火火火木完成签到 ,获得积分10
11秒前
大模型应助妖孽宇采纳,获得10
11秒前
13秒前
积极行天发布了新的文献求助50
13秒前
受伤凌蝶发布了新的文献求助10
16秒前
fusucheng完成签到,获得积分10
17秒前
koi完成签到,获得积分20
17秒前
17秒前
聪明摩托完成签到,获得积分10
17秒前
阿纯完成签到,获得积分10
18秒前
19秒前
肱二头肌完成签到,获得积分10
20秒前
21秒前
小王发布了新的文献求助10
21秒前
多情自古空余恨完成签到,获得积分10
22秒前
Qionglin完成签到,获得积分10
24秒前
Bao完成签到 ,获得积分10
25秒前
25秒前
初夏微凉发布了新的文献求助30
25秒前
26秒前
书霂完成签到,获得积分10
26秒前
优秀含羞草完成签到,获得积分10
27秒前
宓沂完成签到,获得积分10
27秒前
vivre223完成签到,获得积分10
27秒前
量子星尘发布了新的文献求助10
28秒前
受伤凌蝶完成签到,获得积分10
29秒前
wenjiejiang完成签到,获得积分10
30秒前
30秒前
zly完成签到 ,获得积分10
31秒前
高分求助中
【提示信息,请勿应助】关于scihub 10000
Les Mantodea de Guyane: Insecta, Polyneoptera [The Mantids of French Guiana] 3000
徐淮辽南地区新元古代叠层石及生物地层 3000
The Mother of All Tableaux: Order, Equivalence, and Geometry in the Large-scale Structure of Optimality Theory 3000
Global Eyelash Assessment scale (GEA) 1000
Picture Books with Same-sex Parented Families: Unintentional Censorship 550
Research on Disturbance Rejection Control Algorithm for Aerial Operation Robots 500
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 4038388
求助须知:如何正确求助?哪些是违规求助? 3576106
关于积分的说明 11374447
捐赠科研通 3305798
什么是DOI,文献DOI怎么找? 1819322
邀请新用户注册赠送积分活动 892672
科研通“疑难数据库(出版商)”最低求助积分说明 815029