医学
神经纤维层
眼科
视网膜
乳头水肿
视力
灌注
光学相干层析成像
内科学
作者
Akshra Pahuja,Rebika Dhiman,Vasudha Aggarwal,Swati Phuljhele Aalok,Rohit Saxena
出处
期刊:Journal of Neuro-ophthalmology
[Ovid Technologies (Wolters Kluwer)]
日期:2023-06-26
卷期号:Publish Ahead of Print
被引量:2
标识
DOI:10.1097/wno.0000000000001908
摘要
Background: Prospective evaluation of optical coherence tomography (OCT) and OCT angiography (OCT-A) characteristics in different stages of papilledema in idiopathic intracranial hypertension (IIH). Methods: In this prospective, observational study patients of IIH with papilledema were recruited and divided into 3 groups—early/established (Group 1), chronic (Group 2), and atrophic papilledema (Group 3). Peripapillary retinal nerve fiber layer (RNFL) and macular ganglion cell inner plexiform layer (GC-IPL) were recorded on OCT. Peripapillary and macular perfusion was documented at superficial retinal, deep retinal, and choriocapillary level using OCT-A. The investigations were repeated at 3 months. Results: RNFL showed significant thinning in all groups on follow-up with the atrophic group showing maximum thinning (P = 0.01—Group 3). GC-IPL was significantly reduced in all stages of papilledema at baseline compared with the controls. Thinnest GC-IPL was noted in the atrophic group (52.75 ± 7.44 μm; P = 0.00 in Group 3 vs controls) that showed further deterioration on follow-up. On Image J analysis, significant decrease was noted at various levels in the peripapillary and macular perfusion at baseline especially in the atrophic group which showed further deterioration noted on follow-up. The final visual acuity showed a statistically significant weak negative correlation with baseline RNFL (r = −0.306) and GC-IPL (r = −0.384) and moderately negative correlation with baseline superficial peripapillary retinal perfusion (r = −0.553). A significant negative correlation was seen between increasing grade of papilledema and superficial peripapillary retinal perfusion with both Image J and automated indices (r = −0.46; r = −0.61), respectively. Conclusions: GC-IPL may help identify early damage in papilledema even in the presence of thicker RNFL. Significant vascular changes can be observed on OCT-A that may help predict the final visual outcome in papilledema due to IIH.
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