流出物
废水
水解
土霉素
污水处理
化学
制浆造纸工业
化学需氧量
抗生素
色谱法
废物管理
环境科学
有机化学
环境工程
生物化学
工程类
作者
Haodi Feng,Yuqing Hu,Lan Tang,Ye Tian,Zhe Tian,Dongbin Wei,Min Yang,Yu Zhang
标识
DOI:10.1016/j.cej.2023.144409
摘要
With the increasing demand for stringent discharge regulations, the efficient removal of non-biodegradable organic (hard COD) from the biological effluent of pharmaceutical wastewater is becoming increasingly important. Enhanced hydrolysis pretreatment has been used to remove antibiotic potency in antibiotic production wastewater before biological treatment, while the resulting transformation products (TPs) and their contribution to hard COD are largely unknown. Herein, we combine target and non-target analysis aiming to find the major oxytetracycline (OTC) TPs after enhanced hydrolysis pretreatment and to quantify their contribution to the hard COD in biological effluents. Three literature-known and 15 yet unknown TPs, most of which could not be biodegraded, were identified during lab-scale hydrolysis of OTC under neutral conditions. Nuclear magnetic resonance and combined density functional theory were used to determine and infer the molecular structures and possible hydrolysis pathways of them. Furthermore, two stable and dominant TPs, M390s (M390-1 and M390-2), were separated, purified, and structurally identified, which could account for 21.0% and 14.9% − 20.4% (molar ratio) of the initial OTC in the lab-scale and field studies, respectively. More importantly, M390s account for 4.5–––7.8% of the hard COD in biological effluents. The results indicate that the contribution of antibiotic TPs to hard COD in wastewater could not be ignored, and provide more knowledge regarding the efficient treatment of antibiotic production wastewater.
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