Anticancer potential of the S‐heterocyclic ring containing drugs and its bioactivation to reactive metabolites

化学 苯并噻唑 苯并噻吩 噻唑 噻吩 组合化学 杂环化合物 立体化学 生物化学 有机化学
作者
Sumit Maji,Biplab Debnath,Shambo Panda,Tanusree Manna,Arindam Maity,Richa Dayaramani,Rajarshi Nath,Shah Alam Khan,Md Jawaid Akhtar
出处
期刊:Chemistry & Biodiversity [Wiley]
卷期号:21 (7) 被引量:2
标识
DOI:10.1002/cbdv.202400473
摘要

Abstract Sulfur‐containing heterocyclic derivatives have been disclosed for binding with a wide range of cancer‐specific protein targets. Various interesting derivatives of sulfur‐containing heterocyclics such as benzothiazole, thiazole, thiophene, thiazolidinedione, benzothiophene, and phenothiazine, etc have been shown to inhibit diverse signaling pathways implicated in cancer. Significant progress has also been made in molecular targeted therapy against specific enzymes such as kinase receptors due to potential binding interactions inside the ATP pocket. Sulfur‐containing heterocyclic ring metal complexes i. e., benzothiazole, thiazole, thiophene, benzothiophene and phenothiazines are among the most promising active anticancer compounds. However, sulfur heteroaromatic rings, particularly thiophene, are of high structural alert due to their metabolism to reactive metabolites. The mere presence of a structural alert itself does not determine compound toxicity therefore, this review focuses on some specific findings that shed light on factors influencing the toxicity. In the current review, synthetic strategies of introducing the sulfur core ring in the synthesized derivatives are discussed with their structure‐activity relationships to enhance our understanding of toxicity mechanisms and develop safer therapeutic options. The sulfur‐containing marketed anticancer drugs included in this review direct the synthesis of novel compounds and will help in the development of potent, safer sulfur‐based anticancer drugs in near future.
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